{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T06:46:29Z","timestamp":1775976389653,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004048","name":"Kashan University of Medical Sciences","doi-asserted-by":"publisher","award":["40178 2022"],"award-info":[{"award-number":["40178 2022"]}],"id":[{"id":"10.13039\/501100004048","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Opioid use disorder is associated with persistent molecular and cellular changes in the brain, leading to compulsive drug\u2010seeking behaviors. This study aimed to evaluate the effects of olanzapine (OLZ), a D2\u2010like dopamine receptor (D2R) antagonist, on morphine dependence using the conditioned place preference (CPP) model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Morphine\u2010induced CPP was established by subcutaneous (sc) administration of morphine (5\u00a0mg\/kg) for three consecutive days. OLZ at doses of 1.5, 3, and 4.5\u00a0mg\/kg was administered intraperitoneally (ip) during different phases of CPP: acquisition, expression, and extinction. Behavioral assessments included measurement of conditioning scores and locomotor activity. D2R protein expression in the hippocampus (HIP) was evaluated using western blotting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>OLZ reduced both acquisition and expression of morphine\u2010induced CPP in a dose\u2010dependent manner. Additionally, OLZ facilitated extinction by shortening the duration of the extinction phase. Western blot analysis showed a significant reduction in D2R protein expression in the expression and extinction phases in the OLZ\u2010treated groups compared to the morphine\u2010only group. Importantly, effective doses of OLZ did not impair locomotor activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>OLZ attenuates morphine\u2010induced CPP and downregulates D2R expression in the HIP without affecting general locomotor function. These findings suggest a potential therapeutic role for OLZ in the management of opioid\u2010related behaviors. Further research is needed to determine its clinical relevance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71289","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:58:59Z","timestamp":1772999939000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Olanzapine Attenuates the Morphine\u2010Induced Conditioned Place Preference: The Involvement of the D2\u2010Like Dopamine Receptors"],"prefix":"10.1002","volume":"16","author":[{"given":"Farkhondeh Rzazzaghi\u2010","family":"Firozjaei","sequence":"first","affiliation":[{"name":"Clinical Research Development Unit\u2010Matini Kargarnejad Hospital Kashan University of Medical Sciences  Kashan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amineh Sadat Zahiri\u2010","family":"Pour","sequence":"additional","affiliation":[{"name":"Clinical Research Development Unit\u2010Matini Kargarnejad 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