{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T06:46:09Z","timestamp":1775976369522,"version":"3.50.1"},"reference-count":61,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62475179"],"award-info":[{"award-number":["62475179"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine the association between alterations in specific fiber tracts and 6\u2010m gait speed and cognitive function in patients with clinically diagnosed Alzheimer's disease (AD)\u00a0using fixel\u2010based analysis (FBA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants included 26 probable\u00a0AD patients with slow gait speed (AD\u2010SGS), 28 without slow gait speed (AD\u2010nSGS), and 28 normal controls (NC).\u00a0\u00a0All subjects underwent neuropsychological assessment, 6\u2010m gait speed testing, and cranial magnetic resonance imaging (MRI) scans. FBA was employed to derive white matter (WM) fiber metrics, including fiber density (FD), fiber cross\u2010sectional area (FC), and fiber density and cross\u2010sectional area (FDC). After adjustment for age and sex, the mean index values of the fiber tracts showing significant between\u2010group differences were extracted for the correlation between fiber properties, neuropsychological test scores, and parameters related to physical function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>AD\u2010SGS group exhibited significantly reduced FD and FDC in the left inferior fronto\u2010occipital fasciculus (IFOF_L) compared to AD\u2010nSGS group. In probable\u00a0AD patients, FDC values of IFOF_L were positively correlated with global cognitive function, attention and calculation abilities, executive and visuospatial functions, and information processing speed. Furthermore, FD value of IFOF_L was positively correlated with 6\u2010m gait speed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this clinically diagnosed AD patient with slow gait speed, the microstructural integrity of IFOF_L is closely linked to both cognitive decline and motor deficits. The structural deterioration of this tract is associated with the interplay between gait disturbance and impairments in executive and visuospatial functions, and information processing speed in this clinical context.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71298","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T05:15:20Z","timestamp":1773378920000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early Microstructural Changes in the Left Inferior Fronto\u2010Occipital Fasciculus: A Key Factor in Probable Alzheimer's Disease Patients With Slow Gait Speed"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8407-6947","authenticated-orcid":false,"given":"Shan\u2010Wen","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Neurology The Second Affiliated Hospital of Soochow University  Suzhou 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