{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T09:04:15Z","timestamp":1780909455357,"version":"3.54.1"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study aimed to investigate functional brain network characteristics in pediatric tic disorder (TD) patients and explore the effects of aripiprazole treatment on the functional brain network.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Resting\u2010state electroencephalogram (EEG) was recorded from 40 TD patients and 30 matched healthy controls to compare functional brain network differences between TD patients and healthy individuals. Additionally, 26 of these TD patients underwent a 12\u2010week aripiprazole treatment and were evaluated for changes in their functional brain networks before and after treatment. Functional connectivity between brain regions was analyzed using the phase locking value (PLV), and global network topological properties (global efficiency, local efficiency, clustering coefficient, and characteristic path length) were quantified via graph theory.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with controls, TD patients exhibited reduced frontal functional connectivity (Fp2\u2013Fz, Fp2\u2013F4, Fz\u2013F4) but compensatory enhanced connectivity in F7\u2013F3 and C3\u2013Cz. Tourette syndrome patients further exhibited Fp1\u2013Fz hypo\u2010connectivity. Aripiprazole treatment significantly increased global functional connectivity, elevated global and local efficiency and clustering coefficient, and shortened characteristic path length in TD patients. However, frontal hypo\u2010connectivity persisted after treatment partly.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Pediatric TD patients present frontal dysfunction with compensatory adaptations in frontal\u2013temporal connection and sensorimotor networks. Aripiprazole modulates global brain network connectivity and topology but not does not normalize frontal deficits, providing neurophysiological evidence for TD pathophysiology and aripiprazole's therapeutic mechanism.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71331","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T06:44:22Z","timestamp":1774939462000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Functional Brain Network Abnormalities and Aripiprazole's Modulatory Effects in Pediatric Tic Disorder"],"prefix":"10.1002","volume":"16","author":[{"given":"Yuxin","family":"Xiang","sequence":"first","affiliation":[{"name":"Department of Neurology, Wuhan Children's Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilei","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Wuhan Children's Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Jiang","sequence":"additional","affiliation":[{"name":"University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neurology, Wuhan Children's Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8690-397X","authenticated-orcid":false,"given":"Jun","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology Laboratory, Wuhan Children's Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1454-9454","authenticated-orcid":false,"given":"Zhisheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Wuhan Children's Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,30]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-020-06017-0"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1515\/BMT.2007.005"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/s23146434"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mhpa.2023.100534"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2013.11.011"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn223"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2025.138316"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2018.00363"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2024.01.020"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2020.03.031"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073812450317"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2022.846905"},{"issue":"4","key":"e_1_2_13_14_1","first-page":"42","article-title":"Neural Correlates of Impulsivity and Frontal Electroencephalogram Oscillations in Heartfulness Meditators: A Cross\u2010Sectional Study","volume":"31","author":"Krishna D.","year":"2025","journal-title":"Alternative Therapies in Health and Medicine"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.9758\/cpn.2021.19.4.739"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.873148"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2017.05.022"},{"key":"e_1_2_13_18_1","doi-asserted-by":"crossref","first-page":"774","DOI":"10.3389\/fpsyt.2020.00774","article-title":"Current Status, Diagnosis, and Treatment Recommendation for Tic Disorders in China","volume":"11","author":"Liu Z. S.","year":"2020","journal-title":"Frontiers in Psychiatry"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29454"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291723001940"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsc.2021.05.001"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-016-4234-9"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2025.1640967"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2020.01.006"},{"issue":"8","key":"e_1_2_13_25_1","article-title":"Tics and Tourette Syndrome: A Literature Review of Etiological, Clinical, and Pathophysiological Aspects","volume":"14","author":"Ramteke A.","year":"2022","journal-title":"Cureus"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-021-01899-z"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.10.003"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2025.1456146"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.5334\/tohm.190"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/frai.2022.1072801"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2121"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2026.121688"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronb\/gbaf013"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2020.06.021"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X15666170413115754"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-019-0177-6"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cnp.2017.09.003"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-021-03399-5"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23643"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-017-0519-1"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291725102730"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2023.01.046"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-023-03421-1"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci12020151"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.71331","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/brb3.71331","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.71331","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T08:23:53Z","timestamp":1780907033000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.71331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,30]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/brb3.71331"],"URL":"https:\/\/doi.org\/10.1002\/brb3.71331","archive":["Portico"],"relation":{},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,30]]},"assertion":[{"value":"2025-12-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71331"}}