{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T09:49:24Z","timestamp":1791625764565,"version":"4.3.4"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Objective: To clarify the promoting effect of transcranial alternating current stimulation (tACS) at the individual alpha frequency (IAF) of the left posterior parietal cortex (PPC) on working memory (WM) using combined behavioral and electroencephalography (EEG) detection techniques. Methods: This study is a single\u2010blind, randomized, crossover, controlled trial with three groups: the IAF group, the IAF\u20101 group, and the sham group. WM was assessed using the n\u2010back task, while EEG signals were simultaneously collected. Behavioral and EEG\u2010related indicators pre and post stimulation were compared. Results: Compared with pre\u2010stimulation, the average reaction time (RT) in the n\u2010back task significantly decreased (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001) and the d\u2032 value significantly increased (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 001) in all participants post\u2010stimulation. No significant local or whole\u2010brain statistical differences in event\u2010related desynchronization\/synchronization(ERS\/ERD) were found post\u2010stimulation. However, event\u2010related potential (ERP) analysis showed that the P200 amplitude (Fz:\n                    <jats:italic>p<\/jats:italic>\n                    = 0.023, F3:\n                    <jats:italic>p<\/jats:italic>\n                    = 0.017) and P300 amplitude (Fz:\n                    <jats:italic>p<\/jats:italic>\n                    = 0.009, Cz:\n                    <jats:italic>p<\/jats:italic>\n                    = 0.025) in the 3\u2010back task of the IAF group significantly increased after stimulation. In the IAF group, a significant negative correlation was found between \u0394P300 and \u0394RT (Fz:\n                    <jats:italic>r<\/jats:italic>\n                    = \u20130.465,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.039; Cz:\n                    <jats:italic>r<\/jats:italic>\n                    = \u20130.677,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.001). No significant correlation was found between IAF amplitude and behavioral changes (\u0394RT and \u0394d) or ERP changes (\u0394P200 and \u0394P300) (\n                    <jats:italic>p<\/jats:italic>\n                    &gt; 0.05). No significant correlations were found in the IAF\u20101 group or the sham group (\n                    <jats:italic>p<\/jats:italic>\n                    &gt; 0.05). Conclusion: IAF\u2010tACS specially improved the high\u2010load WM performance in healthy participants through increased P300 amplitude in the frontocentral region, which provides a brand\u2010new strategy for precise regulation in the future. Further research are needed to confirm its clinical application.\n                  <\/jats:p>","DOI":"10.1002\/brb3.71337","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T11:17:26Z","timestamp":1778498246000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transcranial Alternating Current Stimulation at the Individual Alpha Frequency Shows Potential Value in Improving Working Memory in Healthy Participants"],"prefix":"10.1002","volume":"16","author":[{"given":"Zhiqiang","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine Taikang Tongji(Wuhan) Hospital  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6376-4518","authenticated-orcid":false,"given":"Yulan","family":"Gao","sequence":"additional","affiliation":[{"name":"Center of Rehabilitation Medicine Zhujiang Hospital, Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6370-7277","authenticated-orcid":false,"given":"Menglin","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation The First Affiliated Hospital of Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longting","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Neurological Rehabilitation Bayi Rehabilitation Center (Sichuan Rehabilitation Hospital)  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4335-7811","authenticated-orcid":false,"given":"Kangling","family":"Wang","sequence":"additional","affiliation":[{"name":"Center of Rehabilitation Medicine Zhujiang Hospital, Southern Medical University  Guangzhou China"},{"name":"School of Rehabilitation Sciences Southern Medical University  Guangzhou China"},{"name":"GuangDong Engineering Technology Research Center of Brain Function Detection and Neuromodulation Rehabilitation Guangzhou China"},{"name":"Key Laboratory of Brain Function Detection and Neuromodulation Intelligent Rehabilitation of Guangdong Higher Education Institutes  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,11]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2025.1548478"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2021.12.001"},{"issue":"2","key":"e_1_2_13_4_1","first-page":"229","article-title":"Aging and n\u2010Back Performance: a Meta\u2010Analysis","volume":"75","author":"Bopp K. 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