{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T09:02:08Z","timestamp":1780909328893,"version":"3.54.1"},"reference-count":64,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ovarian teratomas are increasingly recognized as triggers for autoimmune processes, including neuropsychiatric syndromes. This report describes a rare case of isolated autoimmune psychosis associated with an ovarian teratoma and reviews the relevant literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>A 15\u2010year\u2010old female with a 9\u2010year psychiatric history was initially diagnosed with schizophrenia. Her symptoms, refractory to multiple antipsychotic regimens, included emotional instability, impulsive aggression, and perceptual abnormalities. Abdominal ultrasonography revealed a giant ovarian teratoma with significantly elevated CA19\u20109. Histopathology confirmed neural tissue. Following tumor resection, her psychiatric symptoms resolved dramatically, enabling a return to normal schooling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Literature Review<\/jats:title>\n                    <jats:p>Our systematic review identified 32 cases of teratoma\u2010associated psychosis. Notably, only 2 cases (7.7%) presented without encephalitic features, with one being seronegative for NMDA antibodies. This highlights the exceptional nature of our \u201cpure\u201d psychiatric presentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Ovarian teratomas may be associated with suspected cases of isolated autoimmune psychosis, even in the absence of typical neurological signs or positive autoantibodies. In such instances, CA19\u20109 elevation could serve as a nonspecific clue. Comprehensive imaging remains crucial for patients with atypical, treatment\u2010resistant psychosis to avoid diagnostic delays.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71370","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T04:37:27Z","timestamp":1775018247000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Nine\u2010Year Diagnostic Odyssey of Refractory Psychiatric Symptoms Resolving After Resection of a CA19\u20109\u2010Producing Ovarian Teratoma: A Case Report and Literature Review"],"prefix":"10.1002","volume":"16","author":[{"given":"Wanli","family":"Chen","sequence":"first","affiliation":[{"name":"Liyuan Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyin","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Shantou University Medical College\u2010Faculty of Medicine of University of Manitoba Joint Laboratory of Biological Psychiatry Shantou University Mental Health Center Shantou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nini","family":"Liu","sequence":"additional","affiliation":[{"name":"Shantou University Medical College\u2010Faculty of Medicine of University of Manitoba Joint Laboratory of Biological Psychiatry Shantou University Mental Health Center Shantou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Niu","sequence":"additional","affiliation":[{"name":"Shanghai Hongkou Mental Health Center  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Qiu","sequence":"additional","affiliation":[{"name":"Liyuan Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan 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