{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:14:21Z","timestamp":1792066461500,"version":"4.4.0"},"reference-count":109,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neuropathic pain is a chronic condition initiated by nerve injury and frequently accompanied by affective disturbances, including anxiety and depression. Growing evidence suggests that maladaptive neuroplasticity in the anterior cingulate cortex (ACC) contributes to the persistence and affective dimension of neuropathic pain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To narratively review and critically synthesize current evidence on ACC\u2010related neuroplasticity in neuropathic pain across molecular, circuit, glial, and translational domains.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We narratively reviewed experimental and clinical studies addressing ACC\u2010related molecular signaling, synaptic and circuit remodeling, glial and neuroimmune mechanisms, and interventional approaches relevant to neuropathic pain and its affective dimension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At the molecular level, abnormal ACC synaptic plasticity has been associated with long\u2010term potentiation involving N\u2010methyl\u2010D\u2010aspartate (NMDA) receptors\u2014particularly GluN2B\u2010dependent signaling\u2014while the brain\u2010derived neurotrophic factor (BDNF)\u2013TrkB axis may further contribute to dendritic remodeling and maladaptive synaptic strengthening. At the circuit level, the ACC interacts with limbic regions including the insula and amygdala, within distributed networks that appear to contribute to aversive learning and pain\u2010related affect. At the non\u2010neuronal level, alterations in the ACC microenvironment include astrocyte\u2010linked neuroinflammation and microglia\u2010associated synaptic remodeling, which may shift excitation\u2013inhibition balance. Therapeutically, ACC\u2010targeted strategies are evolving from broad pharmacological modulation toward more spatially specific neuromodulation, although major translational challenges remain, including limited target specificity, cross\u2010species differences, and uncertain causal inference in humans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ACC\u2010related neuroplasticity appears to be an important component of neuropathic pain\u2013affect pathophysiology. Future progress will depend on integrating mechanistic insights with network\u2010level interpretation and improving the precision and clinical translatability of ACC\u2010engaging interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71408","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T06:25:36Z","timestamp":1776234336000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Neuroplasticity\u2010Driven Mechanisms and Therapeutic Targets in the Anterior Cingulate Cortex in Neuropathic Pain"],"prefix":"10.1002","volume":"16","author":[{"given":"Haibing","family":"Xiong","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Banan Hospital Affiliated to Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letai","family":"Li","sequence":"additional","affiliation":[{"name":"Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanlin","family":"Li","sequence":"additional","affiliation":[{"name":"Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutong","family":"Chen","sequence":"additional","affiliation":[{"name":"Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajie","family":"Leng","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery the First Affiliated Hospital of Chongqing Medical University  Chongqing China"},{"name":"Department of Anatomy and Laboratory of Neuroscience and Tissue Engineering Basic Medical College of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Nursing Chongqing Medical University  Chongqing China"},{"name":"Shanghai Jiao Tong University School of Nursing  Shanghai 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