{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T09:49:24Z","timestamp":1791625764548,"version":"4.3.4"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82460226"],"award-info":[{"award-number":["82460226"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Parkinson's disease with mild cognitive impairment (PD\u2010MCI) is a critical dementia prodrome, but its structural neuropathology remains incompletely defined. While hippocampal atrophy is established, volumetric changes in other subcortical structures are poorly characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To perform the first comprehensive meta\u2010analysis quantifying gray matter volume alterations across six subcortical regions in PD\u2010MCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A systematic search of PubMed, Web of Science, Embase, and Cochrane (inception\u2010June 2025) for studies reporting MRI volumetric data comparing PD\u2010MCI and cognitively normal PD (PD\u2010NC) was done. Random\u2010effects models calculated pooled weighted mean differences (WMDs) with 95% confidence intervals (CIs). Heterogeneity (\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      ), publication bias, sensitivity analyses, and meta\u2010regression were assessed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      PD\u2010MCI showed significant bilateral atrophy versus PD\u2010NC in the hippocampus (total WMD = \u20130.65 cm\n                      <jats:sup>3<\/jats:sup>\n                      ), thalamus, putamen, and amygdala, alongside right\u2010lateralized globus pallidus atrophy (WMD = \u20130.08 cm\n                      <jats:sup>3<\/jats:sup>\n                      ). Bilateral caudate nuclei volumes were preserved. Sensitivity analyses confirmed robustness. Meta\u2010regression identified segmentation tools and country as sources of left hippocampal heterogeneity (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). No publication bias was detected.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PD\u2010MCI exhibits a distinct subcortical atrophy signature involving limbic\u2013striato\u2010thalamic networks, with right globus pallidus atrophy as a novel lateralized biomarker. Network\u2010based imaging paradigms are advocated, requiring standardized protocols and longitudinal validation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic Review Registration<\/jats:title>\n                    <jats:p>Identifier PROSPERO (CRD420251051275).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71410","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T16:44:37Z","timestamp":1777308277000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Structural Volumetric Alterations in Parkinson's Disease With Mild Cognitive Impairment"],"prefix":"10.1002","volume":"16","author":[{"given":"Jinhua","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Radiology Affiliated Hospital of Youjiang Medical University for Nationalities  Baise China"},{"name":"School of Medical Laboratory Science Affiliated Hospital of Youjiang Medical University for Nationalities  Baise China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Radiology Affiliated Hospital of Youjiang Medical University for Nationalities  Baise China"},{"name":"School of Medical Laboratory Science Affiliated Hospital of Youjiang Medical University for Nationalities  Baise China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jupeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology Affiliated Hospital of Youjiang Medical University for Nationalities  Baise China"},{"name":"School of Medical Laboratory Science Affiliated Hospital of Youjiang Medical University for Nationalities  Baise China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiology 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