{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T09:02:39Z","timestamp":1780909359608,"version":"3.54.1"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004763","name":"Natural Science Foundation of Inner Mongolia Autonomous Region","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004763","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Substance use disorder (SUD) is a major global health challenge, with methamphetamine use disorder (MUD) being particularly severe due to its high addictiveness and relapse rate. The neurophysiological basis of MUD remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims and Methods<\/jats:title>\n                    <jats:p>This study investigated cross\u2010frequency coupling in 46 male abstinent individuals with MUD to examine multi\u2010scale neural information integration. Electroencephalography (EEG) was recorded during exposure to drug\u2010related and neutral cues. Phase\u2010amplitude coupling (PAC) and phase slope index (PSI) were used to assess local and directed network connectivity, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Cue\u2010induced PAC enhancements correlated significantly with craving: left prefrontal AF3 PAC (10\u201314\u00a0Hz\/60\u201382\u00a0Hz) was negatively correlated (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0\u22120.34 to \u22120.63,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.05), whereas centro\u2010parietal CP2 PAC (6\u201311\u00a0Hz\/74\u201394\u00a0Hz) was positively correlated (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.33\u20130.49,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.05). PSI analysis showed reversed prefrontal\u2010to\u2010occipital flow (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.05) and disrupted centro\u2010parietal to sensorimotor connectivity (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.05) under drug cues.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Drug\u2010related cues may exacerbate craving by weakening top\u2013down prefrontal regulation and amplifying bottom\u2010up sensorimotor drive. PAC and PSI represent promising cue\u2010reactive predictive biomarkers for evaluating the neural substrates of drug cue\u2010induced craving severity in individuals with MUD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71420","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T06:46:29Z","timestamp":1776408389000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Phase\u2010Amplitude Coupling Induced by Drug Cues in Individuals With Methamphetamine Use Disorder During Withdrawal"],"prefix":"10.1002","volume":"16","author":[{"given":"Yu","family":"Tian","sequence":"first","affiliation":[{"name":"School of Digital and Intelligent Industry Inner Mongolia University of Science and Technology  Baotou Inner Mongolia China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Medical Tissue Regeneration Henan Medical University  Xinxiang Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxin","family":"Cheng","sequence":"additional","affiliation":[{"name":"School of Digital and Intelligent Industry Inner Mongolia University of Science and Technology  Baotou Inner Mongolia China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Digital and Intelligent Industry Inner Mongolia University of Science and Technology  Baotou Inner Mongolia China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Digital and Intelligent Industry Inner Mongolia University of Science and Technology  Baotou Inner Mongolia 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Technology  Baotou Inner Mongolia China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Yuan","sequence":"additional","affiliation":[{"name":"School of Automation and Electrical Engineering Inner Mongolia University of Science and Technology  Baotou Inner Mongolia China"},{"name":"Life Sciences Research Center, School of Life Science and Technology Xidian University  Xi'an Shaanxi China"},{"name":"Ganzhou City Key Laboratory of Mental Health The Third People's Hospital of Ganzhou City  Ganzhou Jiangxi China"},{"name":"Engineering Research Center of Molecular and Neuro Imaging Ministry of Education  Xi'an Shaanxi China"},{"name":"Xi'an Key Laboratory of Intelligent Sensing and Regulation of Trans\u2010Scale Life Information, School of Life Science and Technology Xidian University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gengdi","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of 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