{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T09:02:27Z","timestamp":1780909347294,"version":"3.54.1"},"reference-count":55,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82174311"],"award-info":[{"award-number":["82174311"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82004437"],"award-info":[{"award-number":["82004437"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic fatigue syndrome (CFS) is a neurological disorder. Functional connectivity (FC) abnormalities have been implicated in fatigue symptoms, but candidate cortical targets for non\u2010invasive brain stimulation (NIBS) remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We recruited 100 CFS patients and 100 healthy controls (HC) and performed bilateral thalamic seeding to generate FC maps. Two approaches were used to identify candidate stimulation targets: normative analysis based on a public dataset of 1000 healthy individuals and individual analysis based on subject\u2010specific FC patterns. FC peaks were evaluated at both vertex and sphere levels and examined in relation to fatigue severity measured by the 14\u2010item Fatigue Scale (FS14). Finite element analysis (FEA) was used to estimate cortical regions potentially influenced by NIBS. In an additional longitudinal dataset of 35 CFS patients undergoing one month of Tai Chi exercise, we examined associations between exercise\u2010induced FC changes within these regions and changes in fatigue severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Normative analysis identified a negative FC peak in the left lateral occipital cortex (MNI: \u201351.0, \u201377.5, 7.0), near the PO7 electrode, whose FC values were associated with both fatigue severity and exercise\u2010related changes in fatigue. In contrast, individual analysis revealed substantial spatial variability in peak locations with low overlap across participants and inconsistent associations with fatigue severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings suggest that thalamic\u2013surface FC alterations are associated with fatigue symptoms in CFS and the normative analysis may provide a practical reference framework for identifying candidate cortical targets for future NIBS studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71428","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T07:39:55Z","timestamp":1776929995000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Predicting Potential Treatment Targets for Fatigue in Chronic Fatigue Syndrome Using Thalamic Seeding"],"prefix":"10.1002","volume":"16","author":[{"given":"Kang","family":"Wu","sequence":"first","affiliation":[{"name":"Beijing Key Laboratory of Intelligent Drug Research and Development for Mental Disorders, National Clinical Research Center for Mental Disorders, National Center for Mental Disorders, Beijing Anding Hospital Capital Medical University  Beijing China"},{"name":"Advanced Innovation Center for Human Brain Protection Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Zhou","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Intelligent Drug Research and Development for Mental Disorders, National Clinical Research Center for Mental Disorders, National Center for Mental Disorders, Beijing Anding Hospital Capital Medical University  Beijing China"},{"name":"Advanced Innovation Center for Human Brain Protection Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuoran","family":"Li","sequence":"additional","affiliation":[{"name":"Stead Family Department of Pediatrics University of Iowa Carver College of Medicine, Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sitong","family":"Feng","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Intelligent Drug Research and Development for Mental Disorders, National Clinical Research Center for Mental Disorders, National Center for Mental Disorders, Beijing Anding Hospital Capital Medical University  Beijing China"},{"name":"Advanced Innovation Center for Human Brain Protection Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyao","family":"Wu","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Intelligent Drug Research and Development for Mental Disorders, National Clinical Research Center for Mental Disorders, National Center for Mental Disorders, Beijing Anding Hospital Capital Medical University  Beijing China"},{"name":"Advanced Innovation Center for Human Brain Protection Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanzhe","family":"Ning","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Intelligent Drug Research and Development for Mental Disorders, National Clinical Research Center for Mental Disorders, National Center for Mental Disorders, Beijing Anding Hospital Capital Medical University  Beijing China"},{"name":"Advanced Innovation Center for Human Brain Protection Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuangshi","family":"Li","sequence":"additional","affiliation":[{"name":"Dongzhimen Hospital Beijing University of Chinese Medicine  Beijing 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