{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T09:03:12Z","timestamp":1780909392511,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Medical education is associated with high levels of stress that can intensify health\u2010related anxiety, referred to as illness anxiety disorder, medical student syndrome, or nosophobia. This phenomenon often occurs when medical students, after studying a particular illness, start to feel they are having its symptoms and believe they may have the disease. We aimed to determine the prevalence of illness anxiety disorder and its relationship with generalized anxiety among medical students in Karachi.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional study was carried out from February 2025 to May 2025 among MBBS students in Karachi. A pre\u2010validated structured questionnaire, comprising demographic details, the Short Health Anxiety Inventory (SHAI) scale, the Medical Students\u2019 Disease (MSD) Perception Scale, and the MSD Distress Scale, was distributed among 300 students from first to fifth year.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Out of 300 students, significant health\u2010related anxiety (SHAI \u2265 18) was present in 16% (\n                      <jats:italic>n<\/jats:italic>\n                      = 48), and moderate to severe generalized anxiety (GAD\u20107 score \u2265 10) was present in 28% (\n                      <jats:italic>n<\/jats:italic>\n                      = 83) of the students. The highest mean SHAI score was shown by fifth\u2010year students (12.31 \u00b1 1.12), while the highest mean GAD\u20107 scores were shown by second\u2010year students (7.25 \u00b1 0.69). Gender and academic year did not have a statistically significant association with SHAI and GAD\u20107 scores (\n                      <jats:italic>p<\/jats:italic>\n                      &gt; 0.05). Moreover, the Pearson correlation test revealed a low positive but statistically significant correlation between SHAI and GAD\u20107 scores (\n                      <jats:italic>r<\/jats:italic>\n                      = 0.462,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). Linear regression analysis also revealed that the GAD\u20107 score was a significant predictor of the SHAI score, accounting for 21.4% of the variance in the SHAI score (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      = 0.462, 95% CI: 0.425\u20130.663,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001*).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Health\u2010related anxiety and generalized anxiety are prevalent and correlated among the medical students of Karachi. The results of this study emphasize that we must target our mental health interventions to alleviate anxiety\u2010related distress in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71430","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T05:40:27Z","timestamp":1776922827000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence of Illness Anxiety Disorder and Its Relation to Anxiety Among Medical Students in Karachi: A Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"16","author":[{"given":"Wajiha","family":"Aftab","sequence":"first","affiliation":[{"name":"Department of Medicine Dow International Medical College  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hafsa","family":"FNU","sequence":"additional","affiliation":[{"name":"Department of Medicine Dow Medical College  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheikh Abdul Qadir","family":"Jillani","sequence":"additional","affiliation":[{"name":"Department of Medicine Dow Medical College  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar","family":"Imtiaz","sequence":"additional","affiliation":[{"name":"Department of Medicine Dow Medical College  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Ahmed","family":"Zahoor","sequence":"additional","affiliation":[{"name":"Department of Medicine Dow Medical College  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumia","family":"Fatima","sequence":"additional","affiliation":[{"name":"Rawalpindi Medical University  Rawalpindi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muddassir","family":"Khalid","sequence":"additional","affiliation":[{"name":"Department of Community Medicine Nishtar Medical University  Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred","family":"Segawa","sequence":"additional","affiliation":[{"name":"Makerere University College of Health Sciences  Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43045\u2010022\u201000273\u20102"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10608\u2010006\u20109058\u20101"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/0142159X.2010.490282"},{"key":"e_1_2_10_5_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders: DSM\u20105","author":"Bandyopadhyay P. 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