{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T09:49:29Z","timestamp":1791625769170,"version":"4.3.4"},"reference-count":51,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82111530203"],"award-info":[{"award-number":["82111530203"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2502400"],"award-info":[{"award-number":["2022YFC2502400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2502404"],"award-info":[{"award-number":["2022YFC2502404"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Post\u2010stroke cognitive impairment (PSCI) is a frequent and disabling consequence of ischemic stroke. Leukocyte telomere length (LTL), a biomarker of systemic biological aging, has been implicated in cognitive outcomes, but evidence in stroke populations remains limited. We investigated whether baseline LTL and an LTL polygenic risk score (LTL\u2010PRS) are associated with PSCI risk in a large Chinese stroke cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed patients with ischemic stroke or transient ischemic attack (TIA) from the Third China National Stroke Registry\u2013impairment of cognition and sleep (CNSR\u2010III\u2013ICONS) sub study. Baseline LTL was estimated from whole\u2010genome sequencing (WGS) using TelSeq. An 18\u2010SNP LTL\u2010PRS (East\u2010Asian weights) was z\u2010standardized. Cognitive status at 12 months was assessed using the Montreal Cognitive Assessment (MoCA); PSCI was defined as an age\u2010, sex\u2010, education\u2010adjusted norm\u2010referenced threshold (z score \u2264 \u22121.5). Fifty\u2010one participants missing education required for the adjusted PSCI definition were excluded, leaving 923 for analysis. Multivariable logistic regression tested associations of LTL and LTL\u2013PRS with PSCI, with exploratory interaction and stratified analyses by age, sex, and stroke subtype.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>PSCI occurred in 191 of 923 patients (20.7%). Neither continuous LTL nor LTL\u2013PRS was associated with PSCI overall. Exploratory analyses provided nominal evidence of heterogeneity by age (p\u2010interaction = 0.038) and stroke subtype (p\u2010interaction = 0.01), whereas evidence for sex interaction was inconclusive (p\u2010interaction = 0.07). Associations with the MoCA executive function domain were weak and sensitive to covariate adjustment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Baseline telomere metrics showed, at most, modest and context\u2010dependent associations with PSCI. Neither LTL nor this limited\u2010variant LTL\u2013PRS demonstrated overall prognostic utility, highlighting the need for integrated, longitudinal multi\u2010omic approaches for individualized cognitive risk prediction after stroke.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71435","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T16:48:56Z","timestamp":1778777336000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Leukocyte Telomere Length and Its Polygenic Risk Score in Post\u2010Stroke Cognitive Impairment: Evidence From a Multicenter Cohort Study"],"prefix":"10.1002","volume":"16","author":[{"given":"Kunying","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"Department of Neurology Beijing Fengtai Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfeng","family":"Shi","sequence":"additional","affiliation":[{"name":"China National Clinical Research Center For Neurological Diseases  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyi","family":"Yan","sequence":"additional","affiliation":[{"name":"China National Clinical Research Center For Neurological Diseases  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiejie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"China National Clinical Research Center For Neurological Diseases  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"China National Clinical Research Center For Neurological Diseases  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Xu","sequence":"additional","affiliation":[{"name":"China National Clinical Research Center For Neurological Diseases  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuesong","family":"Pan","sequence":"additional","affiliation":[{"name":"China National Clinical Research Center For Neurological Diseases  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixiao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"China National Clinical Research Center For Neurological Diseases  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"China National Clinical Research Center For Neurological Diseases  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[{"name":"China National Clinical Research Center For Neurological Diseases  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"China National Clinical Research Center For Neurological Diseases  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"China National Clinical Research Center For Neurological Diseases  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"China National Clinical Research Center For Neurological Diseases  Beijing 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