{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T09:49:32Z","timestamp":1791625772464,"version":"4.3.4"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Poststroke constipation (PSC) is a prevalent and disabling condition that significantly affects patient quality of life. Although abdominal acupuncture (AA) has demonstrated potential therapeutic effects on PSC, its efficacy remains unclear. This meta\u2010analysis evaluated the efficacy of manual AA (MAA) and abdominal electroacupuncture (AEA) combined with conventional therapy (CT) for PSC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A comprehensive literature search was conducted to identify randomized controlled trials comparing the effects of MAA\u00a0+\u00a0CT or AEA\u00a0+\u00a0CT versus CT alone in PSC treatment. Twelve eligible studies (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0943) were selected. Primary (efficacy and time to first bowel movement [BM]) and secondary (stool shape) outcomes were evaluated. Trial sequential analysis (TSA) was performed to assess cumulative evidence reliability.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both MAA\u00a0+\u00a0CT (relative risk [RR]\u00a0=\u00a01.26, 95% confidence interval [CI]: 1.13\u20131.40) and AEA\u00a0+\u00a0CT (RR\u00a0=\u00a01.28, 95% CI: 1.19\u20131.38) significantly improved efficacy compared with CT alone. Furthermore, MAA\u00a0+\u00a0CT (mean difference [MD]\u00a0=\u00a0\u22120.61, 95% CI: \u22121.02 to \u22120.19) and AEA\u00a0+\u00a0CT (MD\u00a0=\u00a0\u22120.32, 95% CI: \u22121.09 to \u22120.46) reduced the time to first BM, albeit evidence regarding stool shape was inconclusive due to significant heterogeneity. TSA demonstrated unclear cumulative evidence and thus could not determine AA efficacy compared with CT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MAA\u00a0+\u00a0CT and AEA\u00a0+\u00a0CT may effectively improve PSC by enhancing efficacy and shortening the time to first BM. Given the limited number of studies, small sample sizes, and significant heterogeneity, further high\u2010quality trials are required to confirm these findings and optimize the acupuncture regimen for PSC treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71442","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:27:36Z","timestamp":1777523256000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Abdominal Acupuncture in Poststroke Constipation: A Systematic Review and Meta\u2010Analysis With Trial Sequential Analysis"],"prefix":"10.1002","volume":"16","author":[{"given":"Wulam","family":"Rukye","sequence":"first","affiliation":[{"name":"South China Research Center for Acupuncture and Moxibustion, Medical College of Acu\u2010Moxi and Rehabilitation Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongzhi","family":"Yang","sequence":"additional","affiliation":[{"name":"The First College for Clinical Medicine Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjia","family":"Li","sequence":"additional","affiliation":[{"name":"South China Research Center for Acupuncture and Moxibustion, Medical College of Acu\u2010Moxi and Rehabilitation Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nenggui","family":"Xu","sequence":"additional","affiliation":[{"name":"South China Research Center for Acupuncture and Moxibustion, Medical College of Acu\u2010Moxi and Rehabilitation Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhennan","family":"Wu","sequence":"additional","affiliation":[{"name":"South China Research Center for Acupuncture and Moxibustion, Medical College of Acu\u2010Moxi and Rehabilitation Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.04.016"},{"key":"e_1_2_13_3_1","first-page":"29","article-title":"Clinical efficacy of Abdominal Acupuncture Combined With Moxibustion at the Navel for Treating Constipation After Cerebral Infarction","volume":"28","author":"Chen G. 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