{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T13:41:08Z","timestamp":1794490868377,"version":"4.9.1"},"reference-count":188,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Aging is a progressive biological process characterized by the decline of cellular and tissue homeostasis, increasing vulnerability to chronic diseases, especially neurodegeneration. This review examines the role of microRNAs (miRNAs) in brain aging by linking them to the updated hallmarks of aging and key neurobiological processes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>This is an integrative literature review of studies on brain aging, neurodegeneration, and miRNA\u2010mediated regulation. Evidence was synthesized from transcriptomic analyses, experimental studies, and research on circulating systemic factors, including extracellular vesicle\u2010associated miRNAs and plasma proteins. The review focuses on miRNA involvement in genomic stability, nutrient sensing, proteostasis, autophagy, mitochondrial function, telomere maintenance, epigenetic regulation, and cellular senescence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Finding<\/jats:title>\n                    <jats:p>miRNAs regulate multiple aging\u2010related pathways, including DNA repair, IGF\u20101\/AKT\/mTOR signaling, proteostasis, autophagy, and mitochondrial homeostasis. In aging brains, transcriptomic data consistently show reduced expression of genes involved in synaptic plasticity, metabolism, and maintenance, alongside increased inflammatory and immune signaling. Circulating systemic factors and extracellular vesicle miRNAs also influence brain aging, affecting neuroplasticity, cognitive function, and regenerative capacity. These mechanisms contribute to neuroinflammation, synaptic dysfunction, myelin impairment, and neurovascular unit disruption.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>miRNAs are key regulators of brain aging and neurodegeneration and hold promise as biomarkers and therapeutic targets. However, clinical application is limited by disease heterogeneity, context\u2010dependent effects, off\u2010target activity, and challenges in central nervous system delivery. Further research is needed to support safe and effective miRNA\u2010based interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71466","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T06:18:05Z","timestamp":1778048285000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["MicroRNA\u2010Mediated Regulation of Brain Aging Hallmarks: Implications for Neurodegeneration and Neural Recovery"],"prefix":"10.1002","volume":"16","author":[{"given":"Mustafa T.","family":"Ardah","sequence":"first","affiliation":[{"name":"Faculty of Allied Medical Sciences, Hourani Center For Applied Scientific Research Al Ahliyya Amman University  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pareshkumar N.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Pharmacy Gokul Global University  Sidhpur Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omayma Salim","family":"Waleed","sequence":"additional","affiliation":[{"name":"Department of Anesthesia Techniques, Health and Medical Techniques College Alnoor University  Mosul Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamuna","family":"K. 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