{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T09:49:31Z","timestamp":1791625771490,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371345"],"award-info":[{"award-number":["82371345"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82571487"],"award-info":[{"award-number":["82571487"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515013188"],"award-info":[{"award-number":["2024A1515013188"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020084","name":"Guangzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020084","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>As a well\u2010recognized vascular variation, hypoplastic vertebral artery has been recognized as a potential risk for stroke. We aimed to assess the odds of new\u2010onset stroke over a 20\u2010year period in subjects with versus without hypoplastic vertebral artery, exploring how the progression of basilar artery bending mediates the odds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective cohort study, with 20 years of follow\u2010up (2004\u20132024, analysis performed in June 2025). The primary outcome was the occurrence of new\u2010onset posterior circulation infarction during follow\u2010up. Logistic regression models were fitted for new\u2010onset posterior circulation infarction as gender, baseline stroke, baseline posterior circulation infarction, basilar artery stenosis during follow\u2010up, the progression of basilar artery bending, and hypoplastic vertebral artery. Mediation analyses were conducted for vertebral artery stenosis during follow\u2010up, basilar artery stenosis during follow\u2010up, and the progression of basilar artery bending.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 1464 subjects were included, 547 with hypoplastic vertebral artery. During the 20\u2010year follow\u2010up, 91 participants had new\u2010onset posterior circulation infarction. The occurrence of new\u2010onset posterior circulation infarction was significantly associated with progression of basilar artery bending (odds ratio 1.700, 95% confidence interval 1.032\u20132.798,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a00.037) and hypoplastic vertebral artery (odds ratio 1.481, 95% confidence interval 1.019\u20132.003,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a00.015). The proportion of new\u2010onset posterior circulation infarction attributable to hypoplastic vertebral artery was mediated by the progression of basilar artery bending, accounting for approximately 50.2% (95% confidence interval 3.2%\u2013102.4%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Results of this study revealed that hypoplastic vertebral artery was associated with new\u2010onset posterior circulation infarction, and progression of basilar artery bending may serve as a potential intermediate factor in this association.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71488","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T17:04:33Z","timestamp":1778778273000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hypoplastic Vertebral Artery Contributes to Stroke by Promoting Progression of Basilar Artery Bending"],"prefix":"10.1002","volume":"16","author":[{"given":"Jie","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology Wuxi People's Hospital Wuxi Medical Center The Affiliated Wuxi People's Hospital of Nanjing Medical University Nanjing Medical University  Wuxi China"},{"name":"Department of Neurology The Second Affiliated Hospital Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaogang","family":"He","sequence":"additional","affiliation":[{"name":"Department of Neurology Kunshan Hospital of Traditional Chinese Medicine  Kunshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology Changshu No.2 People's Hospital, Affiliated Changshu Hospital of Nantong University  Changshu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeming","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Neurology Guangzhou Panyu District Hexian Memorial Hospital  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanfeng","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Neurology The Second Affiliated Hospital Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiqun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology Guangzhou Hospital of Integrated Traditional and Western Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juehua","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Neurology Wuxi People's Hospital Wuxi Medical Center The Affiliated Wuxi People's Hospital of Nanjing Medical University Nanjing Medical University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Neurology Wuxi People's Hospital Wuxi Medical Center The Affiliated Wuxi People's Hospital of Nanjing Medical University Nanjing Medical University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjun","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Neurology Wuxi People's Hospital Wuxi Medical Center The Affiliated Wuxi People's Hospital of Nanjing Medical University Nanjing Medical University  Wuxi 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