{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T20:46:22Z","timestamp":1782938782069,"version":"3.54.5"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Associations between genetically predicted mood swings and neurological diseases have been suggested. However, the causal relationships between these factors remain undefined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>We used a Mendelian randomization (MR) study to examine the causal relationship of genetically predicted mood swings with the risk of neurological diseases, including stroke, Alzheimer's disease (AD), multiple sclerosis (MS), epilepsy (EP), and headache. The single\u2010nucleotide polymorphisms (SNPs) that exhibited genetic associations with mood swings were utilized as instrumental variables (IV) in the study. We performed MR analyses using the inverse variance weighted (IVW) method as the main approach. Sensitivity analyses were further performed using MR\u2010Egger and MR\u2010PRESSO to assess the robustness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The MR analysis revealed significant causal of mood swings on stroke (OR = 1.300, 95% CI = 1.060\u20131.600;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.012), headache (OR = 1.020, 95% CI = 1.000\u20131.030;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.005), excluding AD (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.548), EP (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.449), MS (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.494).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The findings of this research indicate a possible causal link existing between mood swings and stroke and headache. Additional investigative efforts are requisite for elucidating the underlying biological mechanisms that drive these observed associations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71506","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T17:20:17Z","timestamp":1780075217000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the Causality Between Mood Swings and Neurological Diseases: A Mendelian Randomization Study"],"prefix":"10.1002","volume":"16","author":[{"given":"Na","family":"Li","sequence":"first","affiliation":[{"name":"College of Acupuncture, Massage and Rehabilitation Hunan University of Chinese Medicine Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"He","sequence":"additional","affiliation":[{"name":"College of Acupuncture, Massage and Rehabilitation Hunan University of Chinese Medicine Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanling","family":"Xie","sequence":"additional","affiliation":[{"name":"College of Acupuncture, Massage and Rehabilitation Hunan University of Chinese Medicine Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Acupuncture, Massage and Rehabilitation Hunan University of Chinese Medicine Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Tan","sequence":"additional","affiliation":[{"name":"College of Acupuncture, Massage and Rehabilitation Hunan University of Chinese Medicine Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si","family":"Yuan","sequence":"additional","affiliation":[{"name":"South China Research Center for Acupuncture and Moxibustion, Medical College of Acu\u2010Moxi and Rehabilitation Guangzhou University of Chinese Medicine Guangzhou Guangdong 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