{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T20:46:37Z","timestamp":1782938797670,"version":"3.54.5"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T00:00:00Z","timestamp":1782000000000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neuroendoscopy and external ventricular drainage are commonly considered first\u2010line options for managing thalamic hemorrhage. However, their effectiveness in reducing the risk of rebleeding remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To compare the efficacy and safety of neuroendoscopy versus external ventricular drainage through a systematic review and Bayesian meta\u2010analysis of randomized and nonrandomized studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched PubMed, Embase, and Cochrane for randomized and nonrandomized studies comparing neuroendoscopy with external ventricular drainage in patients with spontaneous thalamic hemorrhage. Data analysis was conducted using a Bayesian random\u2010effects model, with 95% credible intervals (CrI), estimating risk ratios for binary endpoints and mean differences for continuous endpoints.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Six studies comprising 399 patients were included in the meta\u2010analysis. Although the pooled analysis showed no significant difference between groups in rebleeding risk (RR 0.61, 95% CrI 0.26\u20131.46;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 20.3%), neuroendoscopy was associated with an 87.4% posterior probability of reducing rebleeding risk compared with external ventricular drainage. Notably, neuroendoscopy significantly reduced the need for ventriculoperitoneal shunt (RR 0.48, 95% CrI 0.25\u20130.91;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 23.4%), with a 98.6% posterior probability of benefit. It was also associated with favorable prognosis (RR 1.42, 95% CrI 1.05\u20131.94,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 17%), with a 98.84% posterior probability of benefit.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with thalamic hemorrhage, neuroendoscopy was associated with a higher probability of reducing both rebleeding risk and the need for ventriculoperitoneal shunt compared with external ventricular drainage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71526","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T03:25:31Z","timestamp":1782098731000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neuroendoscopy Versus External Ventricular Drainage for Thalamic Hemorrhagic Stroke: A Systematic Review and Bayesian Meta\u2010Analysis"],"prefix":"10.1002","volume":"16","author":[{"given":"Pedro Tchicama","family":"Sikembi","sequence":"first","affiliation":[{"name":"Faculdade De Medicina Universidade Jos\u00e9 Eduardo Dos Santos  Huambo Angola"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo Andr\u00e9s","family":"Vega\u2010Medina","sequence":"additional","affiliation":[{"name":"Ciudad de La Salud, Caja de Seguro Social  Panama City Panam\u00e1"},{"name":"Neuroanatomy Department, Faculty of Medicine, School of Medicine University of Panam\u00e1  Panama City Panama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albe Dias","family":"Batista","sequence":"additional","affiliation":[{"name":"Escola de Ci\u00eancias de Sa\u00fade Universidade de Amazonas  Manaus Amazonas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davi Ricardo Soares Gama de","family":"Amorim","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Pernambuco  Recife Pernambuco Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel F.","family":"Godina\u2010Sanchez","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Universidad de Guadalajara  Guadalajara Jalisco Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Alexandra","family":"Gonz\u00e1lez\u2010Chang","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Panama  Panama City Panama"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,21]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2010.07.041"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/8886004"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjtee.2019.08.003"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10143\u2010012\u20100399\u20109"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2019.7740"},{"key":"e_1_2_12_7_1","unstructured":"Higgins J.2024.Cochrane Handbook for Systematic Reviews of Interventions (Current 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