{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T20:46:20Z","timestamp":1782938780120,"version":"3.54.5"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32500027"],"award-info":[{"award-number":["32500027"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["JCYJ20240813114519026"],"award-info":[{"award-number":["JCYJ20240813114519026"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["JCYJ20250604175713018"],"award-info":[{"award-number":["JCYJ20250604175713018"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["JCYJ20250604175740053"],"award-info":[{"award-number":["JCYJ20250604175740053"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,6]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective<\/jats:title>\n The study aims to investigate changes in brain activity during the verbal fluency task (VFT) and resting\u2010state brain network features in patients with acute carbon monoxide (CO) poisoning using functional near\u2010infrared spectroscopy (fNIRS). We also explored the relationship between cognitive function and the fNIRS\u2010derived features of oxyhemoglobin (Oxy\u2010Hb) concentration curves in the cerebral cortex.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We first performed a cross\u2010sectional study in patients with acute CO poisoning and healthy controls between January and December 2024. The fNIRS\u2010derived features (centroid and mean) of the Oxy\u2010Hb curve in the frontotemporal cortex during VFT were compared between CO poisoning patients and healthy controls.<\/jats:p>\n The functional connectivity of brain networks in patients with acute CO poisoning during the resting state was also analyzed to identify factors representing network features of the cerebral cortex in patients with acute CO poisoning.<\/jats:p>\n We then performed a prospective cohort study to compare the brain activity changes after the hyperbaric oxygen therapy in patients with acute CO poisoning.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The study included 29 patients with CO poisoning and 28 healthy controls. During the VFT, the centroid of the Oxy\u2010Hb curve in Brodmann area 46 was significantly lower in CO poisoning patients compared to the healthy controls (\n p<\/jats:italic>\n \u00a0<\u00a00.01). The centroid and mean values of Brodmann area 46 exhibited a significant positive correlation with Mini\u2010Mental State Examination scores, while the mean value was positively correlated with VFT scores. Mean values in Brodmann areas 11 and 38 were significantly lower in CO poisoning patients (both\n p<\/jats:italic>\n \u00a0<\u00a00.05). The average whole\u2010brain resting\u2010state functional connectivity strength (FCS) was significantly lower in CO poisoning patients compared to healthy controls (\n p<\/jats:italic>\n \u00a0<\u00a00.05), with significant differences in FCS observed in 39 pairs of channels (\n p<\/jats:italic>\n \u00a0<\u00a00.01). Twenty sessions of hyperbaric oxygen therapy resulted in improved FCS (\n p<\/jats:italic>\n \u00a0<\u00a00.01) and centroid values for the Oxy\u2010Hb curve in the left dorsolateral prefrontal cortex during the VFT (\n p<\/jats:italic>\n \u00a0<\u00a00.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The centroid values of the Oxy\u2010Hb curve in the left dorsolateral prefrontal cortex during the VFT, along with the average whole\u2010brain resting\u2010state FCS, potentially could serve as characteristic indicators of brain function in patients with acute CO poisoning.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/brb3.71536","type":"journal-article","created":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T06:55:23Z","timestamp":1781333723000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Altered Dorsolateral Prefrontal Activation in Response to Verbal Fluency Task and Whole\u2010Brain Resting\u2010State Functional Connectivity Strength in Acute Carbon Monoxide Poisoning"],"prefix":"10.1002","volume":"16","author":[{"given":"Jian\u2010Qing","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Hyperbaric Oxygen Affiliated Nanshan Hospital of Shenzhen University Shenzhen Guangdong China"},{"name":"Department of Hyperbaric Oxygen Shenzhen Nanshan People's Hospital Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun\u2010Jun","family":"Liang","sequence":"additional","affiliation":[{"name":"School of Marxism Guangxi University of Science and Technology Liuzhou Guangxi China"},{"name":"Department of Radiology Shenzhen Nanshan People's Hospital Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Xing","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Shenzhen Nanshan People's Hospital Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian","family":"Duan","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Affective and Social Neuroscience, Center for Brain Disorders and Cognitive Sciences Shenzhen University Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing\u2010Ping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Affiliated Nanshan Hospital of Shenzhen University Shenzhen Guangdong 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