{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T20:46:21Z","timestamp":1782938781919,"version":"3.54.5"},"reference-count":73,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neuropathic pain (NP) is associated with maladaptive functional reorganization of the brain, yet the central mechanisms through which massage therapy exerts its analgesic effects remain poorly understood. This study aimed to investigate the impact of acupoint massage on spontaneous neural activity in a rat model of chronic constriction injury (CCI) of the sciatic nerve using resting\u2010state functional magnetic resonance imaging (rs\u2010fMRI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Male Sprague\u2013Dawley rats (\n                      <jats:italic>N<\/jats:italic>\n                      = 45) were randomly allocated into three groups: control, CCI model, and CCI with massage intervention. The massage group received daily acupoint pressing therapy from postoperative day 4 to day 17. Mechanical paw withdrawal threshold (PWT) and thermal paw withdrawal latency (PWL) were assessed at baseline and on days 4, 7, 10, and 17 post\u2010modeling. rs\u2010fMRI scans were acquired at three time points (pre\u2010modeling, day 7, and day 17) using a 9.4T small\u2010animal MRI system. Whole\u2010brain amplitude of low\u2010frequency fluctuations (ALFF) was analyzed to evaluate spontaneous neural activity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CCI modeling induced significant alterations in ALFF across multiple brain regions involved in sensory, affective, and cognitive processing, including the amygdala, hippocampus, insular cortex, and somatosensory cortex. Massage intervention produced a significant group \u00d7 time interaction effect in the left hippocampus (voxel\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.005, cluster\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05 FWE corrected). Specifically, at 7 days post\u2010modeling, ALFF values in the massage group were significantly lower than those in the model group (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.0357), indicating early attenuation of CCI\u2010induced hippocampal hyperactivity. Behaviorally, massage intervention significantly elevated PWT and PWL from day 7 onward (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), with sustained improvement through day 17.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Massage therapy alleviates NP through modulation of spontaneous neural activity across multiple brain regions, with dynamic regulation of hippocampal plasticity emerging as a critical central mechanism. The early normalization of hippocampal hyperactivity may serve as a potential neuroimaging biomarker for massage\u2010mediated analgesia and provides experimental evidence supporting the clinical application of massage for NP management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71545","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T07:56:18Z","timestamp":1781078178000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Massage Regulates Brain Plasticity in Chronic Sciatic Nerve Compression Injury Rats: A Study Based on Resting\u2010State Functional Magnetic Resonance Imaging"],"prefix":"10.1002","volume":"16","author":[{"given":"Lanting","family":"Huang","sequence":"first","affiliation":[{"name":"Fujian University of Traditional Chinese Medicine, Fuzhou  Fujian Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuekun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Fujian University of Traditional Chinese Medicine, Fuzhou  Fujian Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lechun","family":"Chen","sequence":"additional","affiliation":[{"name":"Fujian University of Traditional Chinese Medicine Affiliated Rehabilitation Hospital, Fuzhou  Fujian Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Fujian University of Traditional Chinese Medicine, Fuzhou  Fujian Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"Fujian University of Traditional Chinese Medicine, Fuzhou  Fujian Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanzhen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Fujian University of Traditional Chinese Medicine Affiliated Rehabilitation Hospital, Fuzhou  Fujian Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changzheng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Fujian University of Traditional Chinese Medicine Affiliated Rehabilitation Hospital, Fuzhou  Fujian Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuijin","family":"Chen","sequence":"additional","affiliation":[{"name":"Fujian University of Traditional Chinese Medicine Affiliated Rehabilitation Hospital, Fuzhou  Fujian Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Jiang","sequence":"additional","affiliation":[{"name":"Fujian University of Traditional Chinese Medicine Affiliated Rehabilitation Hospital, Fuzhou  Fujian Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2213-8608","authenticated-orcid":false,"given":"Qiangwen","family":"Xie","sequence":"additional","affiliation":[{"name":"Fujian University of Traditional Chinese Medicine Affiliated Rehabilitation Hospital, Fuzhou  Fujian Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1043-9335","authenticated-orcid":false,"given":"Zhigang","family":"Lin","sequence":"additional","affiliation":[{"name":"Fujian University of Traditional Chinese Medicine Affiliated Rehabilitation Hospital, Fuzhou  Fujian Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000003221"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304\u20103959(88)90209\u20106"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpain.2021.698157"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnw100"},{"key":"e_1_2_11_6_1","unstructured":"Chaban V. 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