{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:56:07Z","timestamp":1791291367412,"version":"4.3.0"},"reference-count":54,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>This longitudinal study investigated whether P300 event\u2010related potential (ERP) amplitude demonstrates group\u2010level and longitudinal differences between stable and progressive mild cognitive impairment (MCI), and whether these electrophysiological changes may serve as preliminary markers associated with Alzheimer's disease (AD) progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>Fifty\u2010four participants, including 27 cognitively unimpaired (CU) individuals and 27 individuals with multi\u2010domain amnestic MCI, underwent EEG recording during a visual oddball task at baseline and follow\u2010up assessment. Within 1 year, 14 MCI participants progressed to AD (pMCI), while 13 remained stable (sMCI). P300 amplitudes were compared across groups and over time, and exploratory receiver operating characteristic (ROC) analyses were conducted to evaluate discriminative performance. Correlations between P300 amplitudes and cognitive measures were also examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings:<\/jats:title>\n                    <jats:p>\n                      Baseline analyses demonstrated significantly reduced P300 amplitudes in both MCI groups compared to CU participants (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), consistent with early cortical dysfunction. Longitudinally, CU and sMCI groups exhibited amplitude decline over time, whereas the pMCI group showed persistently stable but markedly low amplitudes. Exploratory ROC analyses suggested potential group\u2010level discriminative utility for differentiating pMCI from both CU and sMCI participants. In addition, lower P300 amplitudes were significantly associated with poorer global cognitive performance and memory scores.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>These findings suggest that reduced P300 amplitude, particularly at central electrode locations, may represent a preliminary electrophysiological marker associated with progression from MCI to AD. The results support the potential relevance of P300 measures in future prognostic and longitudinal biomarker research in Alzheimer's disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71555","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T16:16:01Z","timestamp":1783527361000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neurophysiological Differentiation of Conversion to Alzheimer's Disease: Longitudinal Changes in P300 Amplitude as an Indicator of Mild Cognitive Impairment Progression"],"prefix":"10.1002","volume":"16","author":[{"given":"Ya\u011fmur","family":"\u00d6zbek","sequence":"first","affiliation":[{"name":"Faculty of Medicine Izmir University of Economics  Izmir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6rsev G.","family":"Yener","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Institute of Health Sciences, Dokuz Eyl\u00fcl University  Izmir T\u00fcrkiye"},{"name":"Faculty of Medicine, Department of Neurology Dokuz Eyl\u00fcl University  Izmir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1037\/0894\u20104105.21.4.458"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0b013e31815068d5"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2009.11.010"},{"issue":"5","key":"e_1_2_14_6_1","first-page":"927","article-title":"ERPs and Dementia Risk in Mild Cognitive Impairment: a Longitudinal Study","volume":"126","author":"Cintra M. 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