{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T20:46:24Z","timestamp":1782938784984,"version":"3.54.5"},"reference-count":56,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["UL1TR000124"],"award-info":[{"award-number":["UL1TR000124"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The brain\u2013heart axis is central to vascular health, yet no imaging biomarkers capture integrated dysfunction across neural and coronary microvascular networks. Although coronary microvascular dysfunction links to cognitive decline, neural correlates connecting cerebral efficiency with coronary physiology remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine whether the Unified Structural and Functional Connectivity (USFC)\u2014a multimodal magnetic resonance imaging (MRI) \u201ctraffic map\u201d of brain network efficiency\u2014predicts coronary endothelial function and cognition in women with ischemia and no obstructive coronary artery disease (INOCA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty\u2010three women with suspected INOCA from the Women's Ischemia Syndrome Evaluation (WISE) study (NCT03876223) underwent invasive coronary function testing, cardiac MRI, cognitive evaluation, and multimodal brain MRI. USFC, structural connectivity (SC), and functional connectivity (FC) were computed for predefined 10 backbone pathways. Support vector regression and logistic classification assessed predictive performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      USFC explained 16%\u201320% more variance in coronary endothelial function, myocardial perfusion reserve, and cognition than SC or FC alone (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). Connectivity between the left caudate\u2013superior medial orbital gyrus and right calcarine\u2013inferior occipital gyrus emerged as robust predictors of crystallized cognition (\n                      <jats:italic>r<\/jats:italic>\n                      = \u20130.78,\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>FDR<\/jats:sub>\n                      &lt; 0.05) and coronary endothelial function (\n                      <jats:italic>r<\/jats:italic>\n                      = 0.70,\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>FDR<\/jats:sub>\n                      &lt; 0.05), respectively. USFC also best discriminated low versus high coronary blood flow (area under the ROC curve [AUC]: USFC 0.622\u00a0vs. SC 0.349 and FC 0.425;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>USFC identifies neuro\u2013cardiac pathways linking cerebral efficiency with coronary endothelial function. These results introduce a sensitive biomarker of systemic vulnerability, highlighting occipital and frontostriatal pathways as shared substrates of dysfunction. USFC offers a mechanistic framework for detecting vascular risk across metabolically demanding tissues.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>ClinicalTrials.gov identifier: NCT03876223<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71559","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T15:42:17Z","timestamp":1782402137000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The \u201cBrain's Traffic Map\u201d Reveals Neural Pathways Linked to Coronary Microvascular Dysfunction in Women"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4609-0956","authenticated-orcid":false,"given":"Arzu C.","family":"Has Silemek","sequence":"first","affiliation":[{"name":"Department of Neurology Cedars\u2010Sinai Medical Center  Los Angeles California USA"},{"name":"Department of Biomedical Sciences and Imaging Biomedical Imaging Research Institute (BIRI) Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0858-4234","authenticated-orcid":false,"given":"Jeffrey C.","family":"Wertheimer","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1311-618X","authenticated-orcid":false,"given":"Janet","family":"Wei","sequence":"additional","affiliation":[{"name":"Barbra Streisand Women's Heart Center Smidt Heart Institute Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0333-567X","authenticated-orcid":false,"given":"Yibin","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Imaging Biomedical Imaging Research Institute (BIRI) Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8467-0938","authenticated-orcid":false,"given":"Mitzi","family":"Gonzales","sequence":"additional","affiliation":[{"name":"Department of Neurology Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8560-8231","authenticated-orcid":false,"given":"Debiao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Imaging Biomedical Imaging Research Institute (BIRI) Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1031-9184","authenticated-orcid":false,"given":"Oana","family":"Dumitrascu","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic College of Medicine and Science  Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2593-0602","authenticated-orcid":false,"given":"Sarah","family":"Kremen","sequence":"additional","affiliation":[{"name":"Department of Neurology Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4588-1206","authenticated-orcid":false,"given":"Zaldy S.","family":"Tan","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Medicine Cedars\u2010Sinai Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3232-8639","authenticated-orcid":false,"given":"Micheal D.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Barbra Streisand Women's Heart Center Smidt Heart Institute Cedars\u2010Sinai Medical Center  Los Angeles California USA"},{"name":"Department of Kinesiology, College of Nursing and Health Innovation The University of Texas at Arlington Arlington Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9933-5155","authenticated-orcid":false,"given":"C. 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