{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:30:25Z","timestamp":1791653425103,"version":"4.3.4"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171512"],"award-info":[{"award-number":["82171512"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Growing evidence implicates gut microbiota dysbiosis in social anxiety disorder (SAD), yet direct causal evidence remains limited. This study investigated whether fecal microbiota transplantation (FMT) from individuals with SAD was associated with general anxiety\u2010like behaviors and accompanying gut microbial and predicted metabolic alterations in mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fecal samples were collected from five patients diagnosed with SAD and five matched healthy controls and transplanted into antibiotic\u2010treated mice. Anxiety\u2010like behaviors were evaluated using the open\u2010field test (OFT) and elevated\u2010plus maze test (EPMT). Gut microbiota composition was assessed by 16S rRNA gene sequencing, microbial functional potential was inferred using PICRUSt2, and plasma tryptophan\u2010pathway metabolites were quantified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mice receiving SAD microbiota (SAD group) showed general anxiety\u2010like behaviors, characterized by more time spent in the periphery of the OFT and fewer entries and less time in the open arms of the EPMT compared to mice receiving healthy control microbiota (control group). Although \u03b1\u2010diversity did not differ significantly, \u03b2\u2010diversity was distinct between groups. The SAD group showed enrichment of Bacteroidota\/Bacteroidales\u2010related bacteria (e.g.,\n                      <jats:italic>Muribaculum<\/jats:italic>\n                      ), whereas the control group had higher abundance of butyrate producers (e.g.,\n                      <jats:italic>Butyricimonas<\/jats:italic>\n                      ). Functional prediction indicated lower predicted abundance of selected DNA\u2010repair and biosynthetic pathways in the SAD group. Plasma tryptophan levels were nominally lower in the SAD group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings suggest that specific gut microbiota alterations and predicted functional pathway changes in individuals with SAD may be associated with anxiety\u2010related behavioral phenotypes, supporting the gut microbiome as a potential contributing factor to the pathophysiology of SAD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71561","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T05:36:26Z","timestamp":1781674586000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Fecal Microbiota Transplantation From Patients With Social Anxiety Disorder Is Associated With General Anxiety\u2010Like Behavior and Gut Microbiota Alterations in Mice"],"prefix":"10.1002","volume":"16","author":[{"given":"Yu\u2010Chao","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Psychiatry Xijing Hospital, Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Xuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Xijing Hospital, Fourth Military Medical University  Xi'an China"},{"name":"Department of Shaanxi Key Laboratory for Animal Conservation Northwest University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Xijing Hospital, Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Toxicology, Shaanxi Key Lab of Free Radical Biology and Medicine, The Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting\u2010Song","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of College of Life Science Shaanxi Normal University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1981-4293","authenticated-orcid":false,"given":"Hua\u2010Ning","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Xijing Hospital, Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8185-0538","authenticated-orcid":false,"given":"Zheng\u2010Wu","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Xijing 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