{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T20:46:39Z","timestamp":1782938799254,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Atherosclerotic cerebral infarction (ACI) is a major cause of disability and mortality worldwide. Atorvastatin provides lipid\u2010lowering and anti\u2010inflammatory benefits, whereas herb\u2010partitioned moxibustion (HPM) may improve circulation and vascular function. This study evaluated the effects of atorvastatin combined with HPM on oxidative stress, blood rheology, and vascular physiological function in patients with ACI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this prospective randomized controlled trial, 100 patients with ACI admitted between December 2023 and October 2024 were randomly assigned to a research group receiving atorvastatin plus HPM (\n                      <jats:italic>n<\/jats:italic>\n                      = 50) or a control group receiving conventional Western medicine alone (\n                      <jats:italic>n<\/jats:italic>\n                      = 50). Treatment lasted 12 weeks. Primary outcomes were serum paraoxonase\u20101 (PON\u20101) and oxidized low\u2010density lipoprotein (ox\u2010LDL). Secondary outcomes included blood rheology indexes, vascular physiological function parameters, clinical efficacy, and adverse reactions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All patients completed the study. Compared with the control group, the research group showed significantly lower whole blood viscosity at high shear (5.10\u00a0\u00b1\u00a01.23\u00a0vs. 6.15\u00a0\u00b1\u00a01.02 mPa\u00b7s), low shear (8.10\u00a0\u00b1\u00a01.17\u00a0vs. 10.46\u00a0\u00b1\u00a01.09 mPa\u00b7s), and plasma viscosity (1.20\u00a0\u00b1\u00a00.28\u00a0vs. 1.88\u00a0\u00b1\u00a00.36 mPa\u00b7s) (all\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). PON\u20101 levels were higher (185.62\u00a0\u00b1\u00a056.28\u00a0vs. 162.20\u00a0\u00b1\u00a054.24 \u00b5g\/L;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.037) and ox\u2010LDL levels were lower (448.24\u00a0\u00b1\u00a080.64\u00a0vs. 500.40\u00a0\u00b1\u00a085.20 kU\/L;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.002). In addition, vascular physiological function improved significantly, with higher peak A, stroke volume, and ejection fraction and lower peak E and MVCF (all\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). The total effective rate was higher in the research group (94.0%\u00a0vs. 82.0%;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.037), with comparable adverse\u2010event rates.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Atorvastatin combined with HPM improved oxidative stress, blood rheology, vascular physiological function, and clinical outcomes in ACI without increasing adverse reactions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71565","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T14:27:01Z","timestamp":1782397621000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Atorvastatin Combined With Herb\u2010Partitioned Moxibustion on PON\u20101 in Patients With Atherosclerotic Cerebral Infarction: A Randomized Controlled Trial"],"prefix":"10.1002","volume":"16","author":[{"given":"Wei","family":"An","sequence":"first","affiliation":[{"name":"The Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine  Harbin Heilongjiang China"},{"name":"Heilongjiang University of Traditional Chinese Medicine  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinlei","family":"Hou","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Wei","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhuo","family":"Zhou","sequence":"additional","affiliation":[{"name":"Heilongjiang University of Traditional Chinese Medicine  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinsheng","family":"Xie","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze","family":"Jin","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linjing","family":"Wang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuzhou","family":"Li","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijia","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Heilongjiang University of Traditional Chinese Medicine  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Chen","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine  Harbin Heilongjiang 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