{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:55:35Z","timestamp":1791291335845,"version":"4.3.0"},"reference-count":47,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Familial neurodevelopmental traits and early relational experiences are increasingly recognized as contributors to heterogeneity in psychosis outcomes. However, little is known about how parental broader autism phenotype (BAP) and adolescent attachment jointly relate to symptom severity and treatment adherence in early\u2010onset psychosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional study enrolled 42 adolescents (aged 12\u201317 years; 88.1% schizophrenia, 11.9% schizoaffective disorder) and their biological parents. Parental BAP was assessed using the Autism Spectrum Quotient\u2010Revised (AQ\u2010R), adolescent attachment with the Psychosis Attachment Measure (PAM), symptom severity with the Scale for the Assessment of Positive\/Negative Symptoms (SAPS\/SANS), and parent\u2010reported medication adherence with the MARS\u20105. Hierarchical multiple regression analyses were conducted to test the hypotheses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Parental BAP did not predict adolescent attachment. However, the model predicting negative symptoms was significant (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 0.439,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.022). Higher paternal AQ\u2010R scores (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      = 0.45,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.016) and avoidant attachment (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      = 0.46,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.005) independently predicted more severe negative symptoms. Medication adherence was not associated with parental BAP; instead, longer DUP was the only robust correlate of poorer adherence (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      = \u22120.56,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.005). Sensitivity analyses using AQ\u201050 scores yielded consistent findings.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Paternal autistic traits and adolescent avoidant attachment may represent independent developmental and relational factors associated with negative symptoms in early psychosis. These findings underscore the need for family\u2010informed assessment and intervention strategies, particularly targeting paternal characteristics and attachment dynamics. Given the modest sample size and cross\u2010sectional design, replication in larger longitudinal cohorts is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71579","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T10:42:07Z","timestamp":1783593727000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Paternal Broader Autism Phenotype and Adolescent Avoidant Attachment as Independent Predictors of Negative Symptoms in Early Psychosis"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6245-396X","authenticated-orcid":false,"given":"Gokcen Ilcioglu","family":"Ekici","sequence":"first","affiliation":[{"name":"Department of Child and Adolescent Psychiatry, Ankara Bilkent City Hospital Affiliated With Ankara Yildirim Beyazit University Faculty of Medicine  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7101-5749","authenticated-orcid":false,"given":"Ceren Sena Akyuz","family":"Coskuner","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry Ankara Bilkent City Hospital  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1970-672X","authenticated-orcid":false,"given":"Merve","family":"Onat","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry Ankara Bilkent City Hospital  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8451-0099","authenticated-orcid":false,"given":"Esra","family":"Cop","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry Ankara Bilkent City Hospital  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"key":"e_1_2_13_2_1","volume-title":"The Scale for the Assessment of Negative Symptoms (SANS)","author":"Andreasen N. 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