{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:54:48Z","timestamp":1791291288870,"version":"4.3.0"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>High\u2010altitude hypoxia imposes persistent physiological stress that may influence psychological health. While personality traits such as neuroticism are known predictors of psychological symptom burden, little is known about whether physiological adaptation\u2014specifically hematologic compensation\u2014is associated with personality\u2010related differences in psychological symptoms under chronically hypoxic conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Healthy adults residing at high altitude completed the Chinese version of the Big Five Inventory\u20102 and provided blood data for RBC, HGB, and HCT.\n                      <jats:italic>k<\/jats:italic>\n                      \u2010Means clustering identified two personality clusters (high vs. low neuroticism) and three hematologic compensation clusters (low, medium, and high). Psychological symptoms across nine domains were assessed using the Symptom Checklist\u201090 (SCL\u201090), a 90\u2010item self\u2010report inventory designed to assess a broad range of psychological symptoms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Finding<\/jats:title>\n                    <jats:p>\n                      A 2 (personality) \u00d7 3 (hematologic compensation) multivariate general linear model revealed no significant interactions on most SCL\u201090 dimensions after controlling for gender, age, and hypoxic exposure time, except for a significant interaction on the SCL\u201090 psychoticism dimension (\n                      <jats:italic>F<\/jats:italic>\n                      (2, 120)\u00a0=\u00a04.026,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.02, \u00a0=\u00a00.063). Simple\u2010effect analysis showed that in the high hematologic compensation group, individuals in the high\u2010neuroticism cluster reported lower SCL\u201090 psychoticism scores than those in the low\u2010neuroticism cluster.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings provide preliminary evidence for a domain\u2010specific interaction between personality profiles and hematologic compensation on the SCL\u201090 psychoticism dimension under chronic high\u2010altitude hypoxia. Importantly, this dimension reflects self\u2010reported subclinical psychoticism\u2010related tendencies rather than clinical psychosis. Because this interaction was not observed across most SCL\u201090 dimensions, the results should be interpreted cautiously and require replication.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71591","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T08:31:04Z","timestamp":1783585864000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Physiological Adaptation Buffers Personality\u2010Linked Psychopathology Under High\u2010Altitude Hypoxia"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1777-345X","authenticated-orcid":false,"given":"Yuan","family":"Li","sequence":"first","affiliation":[{"name":"Xizang Autonomous Region Key Laboratory For High Altitude Brain Science and Environmental Acclimatization Xizang University  Lhasa China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niannian","family":"Wang","sequence":"additional","affiliation":[{"name":"Xizang Autonomous Region Key Laboratory For High Altitude Brain Science and Environmental Acclimatization Xizang University  Lhasa China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhibin","family":"Geng","sequence":"additional","affiliation":[{"name":"China Railway No.10 Engineering Group Co., Ltd.  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Liu","sequence":"additional","affiliation":[{"name":"Xizang Autonomous Region Key Laboratory For High Altitude Brain Science and Environmental Acclimatization Xizang University  Lhasa China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailin","family":"Ma","sequence":"additional","affiliation":[{"name":"Xizang Autonomous Region Key Laboratory For High Altitude Brain Science and Environmental Acclimatization Xizang University  Lhasa China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[{"name":"Xizang Autonomous Region Key Laboratory For High Altitude Brain Science and Environmental Acclimatization Xizang University  Lhasa China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tsc.2024.101539"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2022.104718"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.07.041"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbm081"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.524395"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.21037\/tp\u201022\u2010464"},{"key":"e_1_2_12_8_1","doi-asserted-by":"crossref","unstructured":"Gong W. 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