{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:56:26Z","timestamp":1791291386628,"version":"4.3.0"},"reference-count":62,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Beh\u00e7et's disease is a chronic, relapsing systemic vasculitis that can affect multiple organ systems. Neurological involvement, known as neuro\u2010Beh\u00e7et's disease, occurs in a subset of patients, while psychiatric manifestations\u2014termed neuro\u2010psycho Beh\u00e7et's disease\u2014remain poorly characterized. Understanding the clinical course, pathophysiology, and management of this condition is crucial for interdisciplinary care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To present a detailed case of a patient with neuro\u2010psycho Beh\u00e7et's disease and to explore its pathophysiology, clinical features, psychiatric symptoms, temporal progression, and therapeutic considerations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A clinical case of a 42\u2010year\u2010old male with neuro\u2010Beh\u00e7et's disease who developed a manic episode is described. Concurrently, a systematic review of published cases of neuro\u2010psycho Beh\u00e7et's disease was conducted using the Web of Science, PubMed, and Embase databases on July 19, 2024, following the criteria of the PRISMA\u2010ScR Statement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The clinical case illustrates a multiphasic disease course, with systemic Beh\u00e7et's disease symptoms preceding neurological and subsequently psychiatric manifestations. The systematic review included thirty\u2010four cases, showing diverse psychiatric symptoms, including psychotic, affective, and behavioral disturbances. Neuroimaging frequently revealed parenchymal lesions correlating with psychiatric symptoms. Management typically combined immunosuppressive therapy for Beh\u00e7et's disease with psychiatric treatment, including antipsychotic medications and mood stabilizers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Neuro\u2010psycho Beh\u00e7et's disease represents a clinically and pathophysiologically complex entity. The correlation between parenchymal lesions and psychiatric symptoms supports the hypothesis of a shared neurobiological substrate mediated by inflammatory and immunological mechanisms. A biphasic model, in which initial vascular involvement evolves into neurochemical and structural dysfunction, provides a coherent framework for understanding the relationship between Beh\u00e7et's disease and psychiatric symptoms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71593","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T06:46:08Z","timestamp":1784875568000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Neuro\u2010Beh\u00e7et's Disease and Psychiatric Disorders: From a Case Report to a Systematic Review"],"prefix":"10.1002","volume":"16","author":[{"given":"Jorge","family":"Renau","sequence":"first","affiliation":[{"name":"TXP Research Group Universidad Cardenal Herrera\u2010CEU, CEU Universities  Castell\u00f3n de la Plana Spain"},{"name":"Department of Mental Health Consorcio Hospitalario Provincial De Castell\u00f3n  Castell\u00f3n de la Plana Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2155-9543","authenticated-orcid":false,"given":"Iv\u00e1n","family":"Echeverria","sequence":"additional","affiliation":[{"name":"TXP Research Group Universidad Cardenal Herrera\u2010CEU, CEU Universities  Castell\u00f3n de la Plana Spain"},{"name":"Department of Mental Health Consorcio Hospitalario Provincial De Castell\u00f3n  Castell\u00f3n de la Plana Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Benito","sequence":"additional","affiliation":[{"name":"TXP Research Group Universidad Cardenal Herrera\u2010CEU, CEU Universities  Castell\u00f3n de la Plana Spain"},{"name":"Torrent Mental Health Unit Valencia University General Hospital  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Ses\u00e9","sequence":"additional","affiliation":[{"name":"Department of Mental Health Consorcio Hospitalario Provincial De Castell\u00f3n  Castell\u00f3n de la Plana Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Vicenta","family":"Lucas\u2010Miralles","sequence":"additional","affiliation":[{"name":"TXP Research Group Universidad Cardenal Herrera\u2010CEU, CEU Universities  Castell\u00f3n de la Plana Spain"},{"name":"Department of Mental Health Consorcio Hospitalario Provincial De Castell\u00f3n  Castell\u00f3n de la Plana Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Peraire","sequence":"additional","affiliation":[{"name":"TXP Research Group Universidad Cardenal Herrera\u2010CEU, CEU Universities  Castell\u00f3n de la Plana Spain"},{"name":"Department of Mental Health Consorcio Hospitalario Provincial De Castell\u00f3n  Castell\u00f3n de la Plana Spain"},{"name":"Pre\u2010Departmental Medicine Unit Universitat Jaume I  Castell\u00f3n de la Plana 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