{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:55:37Z","timestamp":1791291337091,"version":"4.3.0"},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004412","name":"T\u00fcrkiye Bilimler Akademisi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Telomere length (TL) has emerged as a candidate predictor for biological aging and age\u2010associated conditions, yet its relationship with structural brain changes remains incompletely characterized. This study aimed to investigate the cross\u2010sectional and longitudinal associations between TL, brain gray matter volume (GMV), white matter volume, and cortical thickness (CT) and to examine individual variability in age\u2010related brain changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study included 196 cognitively healthy individuals aged \u226550 years. All participants underwent baseline MRI and TL measurement from leukocytes. Among them, 46 individuals had a second MRI scan after an average of 4.7 years. Associations between TL and brain structural measures were assessed using multivariate models adjusting for demographic and imaging confounders. Longitudinal volumetric changes were modeled using region\u2010of\u2010interest analyses, whereas regional CT changes were examined using surface\u2010based methods in FreeSurfer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean age of the cohort was 65.9\u00a0\u00b1\u00a08.6 years; 60.9% were women. Median TL was 7.0\u00a0kB (interquartile range [IQR]: 6.0\u20138.4). No significant associations were found between TL and global brain measures in the cross\u2010sectional analysis. However, longitudinal analysis revealed a significant inverse correlation between TL and GMV decline over time (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0\u22120.370,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.012), which remained robust after adjusting for age, sex, follow\u2010up duration, and baseline GMV (standardized\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a0\u22120.32). No significant association was found between TL and overall cortical thinning; however, at the regional level, shorter TL was significantly associated with cortical thinning in the left superior parietal lobule.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>TL may serve as a predictor of age\u2010dependent structural brain changes, with the left superior parietal cortex appearing particularly susceptible within this telomere\u2010brain aging interaction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71608","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T09:33:34Z","timestamp":1784021614000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Leukocyte Telomere Length and Cross\u2010Sectional and Longitudinal Variations in Gray Matter Volume and Cortical Thickness"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1132-3660","authenticated-orcid":false,"given":"Ezgi","family":"Yetim","sequence":"first","affiliation":[{"name":"Department of Neurology Faculty of Medicine Hacettepe University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Akif","family":"Topcuoglu","sequence":"additional","affiliation":[{"name":"Department of Neurology Faculty of Medicine Hacettepe University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuket","family":"Yurur Kutlay","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics School of Medicine Ankara University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajlan","family":"Tukun","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Duzen Laboratory Group  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kader","family":"Karli Oguz","sequence":"additional","affiliation":[{"name":"Division of Neuroradiology Department of Radiology UC Davis Medical Center  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethem Murat","family":"Arsava","sequence":"additional","affiliation":[{"name":"Department of Neurology Faculty of Medicine Hacettepe University  Ankara 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