{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:54:39Z","timestamp":1791291279905,"version":"4.3.0"},"reference-count":49,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271251and82571389X.Z"],"award-info":[{"award-number":["82271251and82571389X.Z"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This cohort study aimed to assess the association between atherogenic index of plasma (AIP) and the risk of delirium in intensive care unit (ICU) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using the Medical Information Mart for Intensive Care IV (MIMIC\u2010IV) database, we analyzed 2,104 adult patients with ICU stays of \u226548 h. The relationship between AIP and delirium risk was investigated using logistic regression and restricted cubic splines (RCS). Subgroup analyses and interaction tests were conducted to assess effect modification. The primary endpoint was the incidence of delirium, with results expressed as odds ratio (OR) and 95% confidence intervals (CI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After adjusting for confounding variables, elevated AIP was significantly associated with delirium risk (OR 1.48, 95% CI 1.15\u20131.91,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.003). RCS analysis revealed a J\u2010shaped nonlinear relationship (\n                      <jats:italic>P<\/jats:italic>\n                      for nonlinearity = 0.01) between AIP and delirium with an inflection point at AIP = 0.33. Subgroup analyses confirmed consistent associations across demographic and clinical strata (all\n                      <jats:italic>P<\/jats:italic>\n                      for interaction &gt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study suggests\u00a0that AIP may serve as an independent biomarker for delirium risk in ICU patients, indicating its potential utility for early identification of high\u2010risk patients. The nonlinear association highlights the need for personalized risk assessment based on AIP values.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71613","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T06:11:29Z","timestamp":1784182289000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Atherogenic Index of Plasma for the Prediction of Delirium in ICU Patients: A Retrospective Cohort Study Based on the MIMIC\u2010IV Database"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8327-4351","authenticated-orcid":false,"given":"Shuai","family":"Miao","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center Nanjing Medical University  Wuxi Jiangsu Province 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Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center Nanjing Medical University  Wuxi Jiangsu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center Nanjing Medical University  Wuxi Jiangsu Province 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