{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T13:31:08Z","timestamp":1789047068746,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive neuromodulation technique that uses magnetic fields to stimulate or inhibit specific populations of neurons in the brain. rTMS targeting the cortex has emerged as an effective treatment for chronic pain. It is established that stress can heighten pain sensitivity, a condition termed stress\u2010induced hyperalgesia (SIH). However, neither direct evidence for rTMS treatment of SIH nor a clear understanding of its therapeutic mechanisms has been established.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this article, we studied the effectiveness of rTMS in SIH using a rat CFA (complete Freund's adjuvant)\u00a0+\u00a0SPS (single\u2010prolonged stress)\u2010induced model. Following SPS\u00a0+\u00a0CFA treatment, a significant enhancement in both medial prefrontal cortex (mPFC) microglia activation by immunohistochemistry and Western blot analyses and mechanical allodynia was observed, as compared with the application of SPS or CFA alone. Compared to the untreated SPS\u00a0+\u00a0CFA model group, 10\u00a0Hz rTMS treatment significantly elevated the paw withdrawal threshold. This effect was also significantly greater than that observed in the group receiving 1\u00a0Hz rTMS. Moreover, the application of 10\u00a0Hz rTMS inhibited microglial activation in the SPS\u00a0+\u00a0CFA model, along with alleviating associated anxiety\u2010like behaviors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Finds and Conclusion<\/jats:title>\n                    <jats:p>These results suggest that rTMS might have an effect on the treatment of SIH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71635","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T14:57:44Z","timestamp":1785250664000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Repetitive Transcranial Magnetic Stimulation of the mPFC Ameliorates Stress\u2010Induced Hyperalgesia by Alleviating Microglia Activation in Rats"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6413-8795","authenticated-orcid":false,"given":"Jian","family":"Qi","sequence":"first","affiliation":[{"name":"Department of Orthopedics The 960th Hospital of PLA  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0565-0841","authenticated-orcid":false,"given":"Chen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Second Hospital of Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The 960th Hospital of PLA  Jinan China"},{"name":"Jinzhou Medical University, The 960th Hospital of the Chinese People's Liberation Army Joint Logistic Support Force Postgraduate Training Base  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The 960th Hospital of PLA  Jinan China"},{"name":"Jinzhou Medical University, The 960th Hospital of the Chinese People's Liberation Army Joint Logistic Support Force Postgraduate Training Base  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.105.161801"},{"key":"e_1_2_9_3_1","unstructured":"Anderson J. 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