{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:05:53Z","timestamp":1789049153423,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study investigated the independent and interactive effects of bipolarity (subthreshold bipolar spectrum features) on multidimensional clinical profiles in individuals with insomnia, using data from a comprehensive deep phenotyping study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 338 participants (252 with insomnia, 86 normal sleeper controls) from the SOMDAY deep phenotyping study were classified into a 2 \u00d7 2 factorial design: Sleep Status (Insomnia vs. Control) \u00d7 Bipolarity (Korean version of the Mood Disorder Questionnaire [K\u2010MDQ] \u2265 7\u00a0vs. &lt; 7). Two\u2010way analyses of covariance, adjusted for age and sex, were conducted across 14 validated clinical scales. Benjamini\u2013Hochberg false discovery rate correction was applied, with rank\u2010transformed sensitivity analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sleep Status showed significant main effects across 13 of 14 scales (all false discovery rate\u2010corrected\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05), with the largest effects on sleep quality (Pittsburgh Sleep Quality Index [PSQI], partial \u03b72 = 0.230) and circadian rhythm disturbance (Korean version of the Biological Rhythms Interview of Assessment in Neuropsychiatry [K\u2010BRIAN], partial \u03b72 = 0.210). Bipolarity was independently associated with elevations in 10 of 14 scales, with the strongest effects on anxiety (Generalized Anxiety Disorder\u20107, partial \u03b72 = 0.059), anxiety sensitivity (Body Sensations Questionnaire, partial \u03b72 = 0.049), and depression (Patient Health Questionnaire\u20109, partial \u03b72 = 0.041). No interaction effects survived correction, indicating predominantly additive effects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Bipolarity, indexed by the K\u2010MDQ, exerts statistically independent main effects associated with greater psychological distress, anxiety sensitivity, and circadian vulnerability, operating additively with insomnia status across both insomnia patients and normal sleepers. These findings support the integration of bipolar spectrum screening into sleep medicine assessment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71642","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T14:46:20Z","timestamp":1785249980000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bipolarity as an Independent Correlate of Clinical Profiles in Insomnia: A Factorial Analysis Across Multiple Clinical Domains"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1323-7561","authenticated-orcid":false,"given":"Sujin","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Psychiatry Korea University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4874-0265","authenticated-orcid":false,"given":"Seung Pil","family":"Pack","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Bioinformatics Korea University  Sejong Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9560-2383","authenticated-orcid":false,"given":"Heon\u2010Jeong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Korea University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1663-9680","authenticated-orcid":false,"given":"Chul\u2010Hyun","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Korea University College of Medicine  Seoul Republic of Korea"},{"name":"Department of Biomedical Informatics Korea University College of Medicine  Seoul Republic of Korea"},{"name":"Department of Medical Education Korea University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406\u2010011\u20100228\u20100"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0165\u20101781(99)00019\u20100"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165\u20101781(89)90047\u20104"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1037\/\/0022\u2010006x.52.6.1090"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.4082\/kjfm.2016.37.6.323"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.30773\/pi.2018.10.21.1"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep31846"},{"key":"e_1_2_12_9_1","volume-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen J.","year":"1988"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.2307\/2530051"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/27.2.285"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2009.08.003"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2008.08010098"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010clinpsy\u2010032210\u2010104550"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201001215\u20108"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/14.6.540"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2008.07.008"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsc.2017.12.004"},{"key":"e_1_2_12_19_1","volume-title":"Resilience (Korean Resilience Quotient\u201053)","author":"Kim J. 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