{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T06:10:58Z","timestamp":1789711858798,"version":"4.0.1"},"reference-count":51,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study aimed to systematically analyze the developmental trajectory, research landscape, and thematic evolution of tauopathy research from 2003 to 2025 using bibliometric methods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 6752 publications retrieved from the Web of Science Core Collection (WoSCC) were analyzed using the R package bibliometrix and VOSviewer to construct bibliometric networks, including co\u2010authorship, co\u2010citation, and keyword co\u2010occurrence analyses. Scimago Graphica was used to visualize international collaboration patterns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The annual number of publications on tauopathy increased markedly during the period 2003\u20132025, reflecting sustained global research interest. The United States was the leading contributor in both publication output and citation impact, while the University of Pennsylvania emerged as a key institution. Among individual researchers, the most productive authors and influential scholars were identified through publication output and citation\u2010based metrics. Citation analysis highlighted the enduring impact of highly cited studies, particularly those establishing key biomarker frameworks for Alzheimer\u2019s disease research.Keyword\u2010based analysis further revealed a shift from traditional mechanistic studies toward more integrative research themes, such as tau\u2013amyloid\u2010\u03b2 interactions, neurodegeneration, and glial involvement, alongside continued interest in tau\u2010targeted therapeutic strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This bibliometric analysis provides a quantitative and structured overview of the global tauopathy research landscape. Beyond confirming established patterns, it captures the dynamic evolution of research priorities and identifies emerging directions, offering a data\u2010driven basis for future investigations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71645","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T06:40:51Z","timestamp":1786516851000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Emerging Trends and Hot Spots in Tauopathy Research (2003\u20132025): A Bibliometric Analysis"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6941-6230","authenticated-orcid":false,"given":"Si\u2010Yao","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Acupuncture and Rehabilitation Affiliated Hospital of Nanjing University of Chinese Medicine Nanjing Jiangsu Province China"},{"name":"Department of Treatment of Disease 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