{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T13:31:10Z","timestamp":1789047070176,"version":"build-2803163510"},"reference-count":54,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sepsis is a common systemic inflammatory disease clinically observed in patients with severe trauma or infectious diseases. Lipopolysaccharide (LPS) serves as a classic tool for studying infection\u2010related neuroinflammation and behavioral changes. Research indicates that LPS can induce peripheral inflammation and neuroinflammation, leading to synaptic dysfunction and neurobehavioral abnormalities. Furthermore, studies suggest that stress can increase susceptibility to inflammation. Intermittent hypoxia, a core pathological feature of obstructive sleep apnea syndrome, induces low\u2010grade chronic inflammation in the central nervous system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study investigates whether intermittent hypoxia exacerbates LPS\u2010induced cognitive impairment, depression, and anxiety\u2010like behaviors, and explores its potential mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adult mice were treated with LPS alone or in combination with daily 8\u2010h intermittent hypoxia via a hypoxia chamber. Depression and anxiety\u2010like behavior were assessed using the tail suspension, forced swim, elevated plus maze, and open field tests. Spatial learning and memory were measured using the Morris water maze test. Pro\u2010inflammatory cytokines and levels of genes and proteins of synaptic\u2010related proteins were detected using enzyme\u2010linked immunosorbent assay, western blotting, and real\u2010time fluorescence\u2010based quantitative PCR, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>LPS\u2010induced impaired cognitive function, increased depression\u2010like and anxiety\u2010like behaviors, elevated pro\u2010inflammatory cytokines, and decreased mRNA and protein levels of synapse\u2010related proteins, synaptosomal\u2010associated protein of 25\u00a0kDa, synaptotagmin\u20101, synaptophysin, and postsynaptic density protein\u201095 in adult male mice. Intermittent hypoxia exacerbated these adverse effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Intermittent hypoxia exacerbates LPS\u2010induced neurobehavioral abnormalities, which are associated with neuroinflammation and alterations in synapse\u2010related proteins.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71653","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T08:10:21Z","timestamp":1785917421000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intermittent Hypoxia Exacerbates Lipopolysaccharide\u2010Induced Neurobehavioral Abnormalities: The Role of Neuroinflammation and Synaptic\u2010Related 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