{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T07:44:14Z","timestamp":1792395854209,"version":"4.4.0"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>Poststroke delirium (PSD) is common and prognostically relevant, yet under\u2010detected. Mechanistic and biomarker research is constrained by reliance on an intermittently observed binary phenotype, while delirium reflects one severity level on a continuum of delirium\u2010related encephalopathy. Quantitative EEG (qEEG) may capture encephalopathy endotypes more directly and enable severity\u2010spectrum characterization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this prospective, single\u2010center, observational cohort study, 87 consecutive patients with acute ischemic stroke or transient ischemic attack were assessed within 48\u00a0h using the Confusion Assessment Method (CAM). A 64\u2010channel EEG was recorded at enrollment; spectral power (delta\/theta\/alpha\/beta) and functional connectivity metrics (phase lag index; amplitude envelope correlation corrected [AECc]) were computed. Neuroinflammatory and systemic biomarkers were quantified from routine serum sampling in an exploratory, add\u2010on subcohort (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a031).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      PSD occurred in 28 of 87 (32%). PSD was characterized by spectral slowing and altered AECc. A multivariable qEEG model discriminated PSD with AUC\u00a0=\u00a00.892 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and overall accuracy of 81.4% (non\u2010delirium 89.8%, delirium 63.0%). In the paired EEG plus serum subset, nominal exploratory correlations between qEEG metrics and selected biomarkers suggested links between network dysfunction and inflammatory signaling, including inverse correlations of theta\u2010band AECc with VILIP\u20101 (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0\u22120.454,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.045) and CX3CL1 (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0\u22120.604,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.005), whereas biomarker\u2013phenotype associations were less consistent.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>qEEG connectivity provides an encephalopathy\u2010proximal readout that can detect PSD and may characterize delirium\u2010related endotypes beyond the intermittently observed clinical phenotype. Findings require validation in larger, multicenter cohorts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71678","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T04:21:13Z","timestamp":1788754873000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Quantitative EEG\u2010Based Detection of Poststroke Delirium Endotypes and Their Association With Biomarkers of Inflammation"],"prefix":"10.1002","volume":"16","author":[{"given":"Max","family":"Bl\u00fccher","sequence":"first","affiliation":[{"name":"Department of Neurology University Medicine Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nursena","family":"Armagan","sequence":"additional","affiliation":[{"name":"Department of Neurology University Medicine Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna\u2010Christina","family":"Osswald","sequence":"additional","affiliation":[{"name":"Department of Neurology University Medicine Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annerose","family":"Mengel","sequence":"additional","affiliation":[{"name":"Department of Neurology &amp; Stroke University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antje","family":"Vogelgesang","sequence":"additional","affiliation":[{"name":"Department of Neurology University Medicine Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Ruhnau","sequence":"additional","affiliation":[{"name":"Department of Neurology University Medicine Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8159-2658","authenticated-orcid":false,"given":"Robert","family":"Fleischmann","sequence":"additional","affiliation":[{"name":"Department of Neurology University Medicine Greifswald  Greifswald 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