{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T07:44:18Z","timestamp":1792395858037,"version":"4.4.0"},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Mounting evidence suggests beta amyloid (A\u03b2) is not the sole initiating driver of cognitive decline in Alzheimer's disease (AD). This study explores whether there is an association between cognitive decline over eight years and A\u03b2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Data from 48 participants in the Dallas Lifespan Brain Study (DLBS) were analyzed in the present study. Prior to selection, participants were classified as A\u03b2\n                      <jats:sup>+<\/jats:sup>\n                      or A\u03b2\n                      <jats:sup>\u2212<\/jats:sup>\n                      based on global A\u03b2 deposition. All 24 A\u03b2\n                      <jats:sup>+<\/jats:sup>\n                      participants with complete data for the purposes of the present study were sex\u2010 and age\u2010matched with an A\u03b2\n                      <jats:sup>\u2212<\/jats:sup>\n                      participant and assorted into two respective A\u03b2 groups. Cognitive decline across episodic memory, working memory, processing speed, and reasoning was then compared between the two groups over an 8\u2010year observation period.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      An association between cognitive decline over 8 years and the A\u03b2 group was observed in reasoning but not across episodic memory, working memory, and processing speed. Still, there were differences between the two groups that reached significance on an episodic memory task (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.035) and trended toward significance on an encompassing episodic memory composite (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.057). Post\u2010hoc comparisons revealed these differences were only significant at epoch 1. Broad declines in cognition were also found over the observation period, irrespective of A\u03b2 group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results contribute to the mounting evidence that suggests A\u03b2 is not the sole initiating driver of cognitive decline in AD. However, the present study has limitations, including a relatively small sample size that must be accounted for when considering the null findings to prevent overinterpretation. Future work should validate our results in larger, similarly controlled samples and model additional AD biomarkers and risk factors to explore different mechanisms for cognitive decline in AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71684","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T04:58:56Z","timestamp":1789534736000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluating the 8\u2010Year Association Between Cognition and Beta Amyloid in the Dallas Lifespan Brain Study Cohort"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9148-4401","authenticated-orcid":false,"given":"Joshua","family":"David","sequence":"first","affiliation":[{"name":"School of Behavioral and Brain Sciences The University of Texas at Dallas  Richardson Texas 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