{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T13:30:19Z","timestamp":1789047019322,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301312"],"award-info":[{"award-number":["82301312"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171151"],"award-info":[{"award-number":["82171151"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Residual dizziness (RD) is commonly observed in patients with benign paroxysmal positional vertigo (BPPV) following successful canalith repositioning procedures. Targeted vestibular rehabilitation therapy (tVRT) is a novel strategy designed to address specific vestibular deficits. This study aims to investigate whether tVRT can accelerate the vestibular rehabilitation process in patients with RD of BPPV and explore its neural mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Ninety\u2010four BPPV patients with RD were enrolled and received a 4\u2010week tVRT program tailored to utricular deficits. A rs\u2010fMRI subgroup (\n                      <jats:italic>n<\/jats:italic>\n                      = 43) was used to assess brain activity and functional connectivity (FC) before and after successful intervention.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The tVRT group demonstrated significantly lower DHI and SAS scores and higher ABC score. rs\u2010fMRI revealed that tVRT increased ALFF in the right superior temporal gyrus (STG), positively correlated with ABC scores, and enhanced ReHo in the right anterior cingulate cortex (ACC). The tVRT group showed enhanced STG\u2010cerebellar tonsil connectivity, along with reduced STG\u2010posterior cingulate cortex connectivity. Using right ACC as seed, FC between the ACC and lingual gyrus was increased. STG\u2013cerebellar tonsil FC was negatively correlated with RD duration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>tVRT accelerates vestibular compensation in patients, which may be mediated by enhanced neural activity and reorganization of brain networks involved in vestibular processing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71696","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T06:37:15Z","timestamp":1787294235000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeted Vestibular Rehabilitation Accelerates Symptom Relief by Promoting Vestibular Compensation in BPPV Patients With Residual Symptoms: Evidence From Resting\u2010State fMRI"],"prefix":"10.1002","volume":"16","author":[{"given":"Gendi","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery The Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Center of Dizziness and Tinnitus Diagnosis and Treatment The Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinfei","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery The Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Center of Dizziness and Tinnitus Diagnosis and Treatment The Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiling","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery The Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Center of Dizziness and Tinnitus Diagnosis and Treatment The Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingwei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery The Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Center of Dizziness and Tinnitus Diagnosis and Treatment The Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiashu","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery The Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Center of Dizziness and Tinnitus Diagnosis and Treatment The Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery The Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Center of Dizziness and Tinnitus Diagnosis and Treatment The Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhicheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery The Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Center of Dizziness and Tinnitus Diagnosis and Treatment The Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangli","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery The Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Center of Dizziness and Tinnitus Diagnosis and Treatment The Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"issue":"3","key":"e_1_2_13_2_1","first-page":"S1","article-title":"Clinical Practice Guideline: Benign Paroxysmal Positional Vertigo (Update)","volume":"156","author":"Bhattacharyya N.","year":"2017","journal-title":"Otolaryngology\u2013Head and Neck Surgery: Official Journal of American Academy of Otolaryngology\u2010Head and Neck Surgery"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743\u20100003\u20109\u201077"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2024.1388213"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14570"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234\u2010024\u201003535\u20104"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.70175"},{"issue":"2","key":"e_1_2_13_8_1","article-title":"Vestibular Rehabilitation for Unilateral Peripheral Vestibular Dysfunction","volume":"1","author":"Hillier S. 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