{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T13:29:40Z","timestamp":1789046980614,"version":"build-2803163510"},"reference-count":51,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Systemic low\u2010grade inflammation and subtle executive\u2010function decline can emerge during midlife, yet short\u2010term lifestyle approaches remain understudied. This single\u2010arm interventional pre\u2013post study examined whether a 4\u2010week supervised resistance\u2010training program was associated with changes in circulating inflammatory biomarkers, plasma brain\u2010derived neurotrophic factor (BDNF), and executive\u2010task performance in healthy midlife adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Five hundred healthy adults aged 50\u201365 years entered a supervised resistance\u2010training program conducted three times weekly for 4 weeks after screening 647 individuals. Assessments were completed at baseline and 72\u00a0h after the final training session. Primary full\u2010cohort outcomes included plasma interleukin\u20106 (IL\u20106), tumor necrosis factor\u2010alpha (TNF\u2010\u03b1), BDNF, two\u2010back accuracy, two\u2010back reaction time, Stroop interference, and Stroop accuracy. Adherence was recorded prospectively and summarized as \u226511 sessions (\n                      <jats:italic>n<\/jats:italic>\n                      = 312), 10 sessions (\n                      <jats:italic>n<\/jats:italic>\n                      = 146), and &lt;10 sessions (\n                      <jats:italic>n<\/jats:italic>\n                      = 42). Full\u2010cohort analyses were treated as the primary analyses, while per\u2010protocol, adherence\u2010stratified, and sensitivity analyses were reported as secondary analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the full analytic cohort, IL\u20106 decreased from 2.83 \u00b1 1.60 to 2.09 \u00b1 1.34 pg\/mL, TNF\u2010\u03b1 decreased from 3.61 \u00b1 1.07 to 3.12 \u00b1 0.96 pg\/mL, and BDNF increased from 23.4 \u00b1 5.6 to 26.1 \u00b1 6.2\u00a0ng\/mL. The corresponding mean changes were \u22120.74 pg\/mL for IL\u20106, \u22120.49 pg\/mL for TNF\u2010\u03b1, and +2.7\u00a0ng\/mL for BDNF, with all paired comparisons statistically significant. Executive\u2010task performance also improved, with two\u2010back accuracy increasing from 83.7 \u00b1 8.9% to 87.6 \u00b1 7.2%, two\u2010back reaction time decreasing from 690 \u00b1 89 to 652 \u00b1 82\u00a0ms, Stroop accuracy increasing from 89.8 \u00b1 7.4% to 91.9 \u00b1 6.2%, and Stroop interference decreasing from 238 \u00b1 47 to 211 \u00b1 41\u00a0ms. Secondary adherence\u2010stratified analyses showed larger numerical biomarker and cognitive changes among participants completing \u226511 sessions, but these subgroup findings were interpreted descriptively because adherence groups were not randomized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In healthy midlife adults, a 4\u2010week supervised resistance\u2010training program was associated with lower circulating IL\u20106 and TNF\u2010\u03b1, higher plasma BDNF, and modest improvement in working\u2010memory and inhibitory\u2010control performance. These findings reflect within\u2010cohort pre\u2013post associations rather than comparative efficacy and should be interpreted cautiously because of the single\u2010arm design, absence of central biomarkers, and short follow\u2010up duration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71723","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T04:53:46Z","timestamp":1787720026000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Exploratory Study of the Short\u2010Term Association of Resistance Training With Circulating Inflammatory Biomarkers, Plasma Brain\u2010Derived Neurotrophic Factor, and Cognitive Function in Healthy Midlife Adults"],"prefix":"10.1002","volume":"16","author":[{"given":"Yu","family":"Ziyan","sequence":"first","affiliation":[{"name":"School of Humanities Shunde Vocational and Technical University  Foshan Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7552-4966","authenticated-orcid":false,"given":"Chen","family":"Deqin","sequence":"additional","affiliation":[{"name":"College of Physical Education Beibu Gulf University  Qinzhou Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Fanyue","sequence":"additional","affiliation":[{"name":"School of Humanities Shunde Vocational and Technical University  Foshan Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3181915670"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2024.112662"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2023.112141"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1131214"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.52403\/ijhsr.20221023"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1519\/jpt.0000000000000443"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2013.04.024"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2024.1496544"},{"key":"e_1_2_10_10_1","unstructured":"Borg G.1998.Borg's Perceived Exertion and Pain Scales.Human Kinetics."},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1249\/00005768\u2010198205000\u201000012"},{"issue":"3","key":"e_1_2_10_12_1","first-page":"273","article-title":"PAR\u2010Q+ and ePARmed\u2010X+: New Risk Stratification and Physical Activity Clearance Strategy for Physicians and Patients Alike","volume":"59","author":"Bredin S. 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