{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:03:28Z","timestamp":1790661808083,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective<\/jats:title>\n To investigate the natural course of cerebral small vessel disease (CSVD) manifested as pure thalamic infarction (PTI) and identify predictors of 90\u2010day clinical prognosis and 1\u2010year recurrent major adverse cardiovascular\/cerebrovascular events (MACE).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This retrospective cohort study analyzed 251 consecutive thalamic infarction patients admitted between January 2016 and May 2024. Participants were classified into PTI (\n n<\/jats:italic>\n = 187) or combined\u2010type thalamic infarction (CTI,\n n<\/jats:italic>\n = 64). Primary endpoints included poor 90\u2010day clinical prognosis (modified Rankin Scale [mRS] \u2265 2) and 1\u2010year MACE (composite of stroke, acute myocardial infarction, and cardiovascular death). Intergroup comparisons utilized Pearson Chi\u2010square or Mann\u2013Whitney U tests, with variables showing\n p<\/jats:italic>\n \u2264 0.10 in univariate analysis entered into multivariate logistic regression models.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Compared with CTI, PTI patients demonstrated lower baseline National Institutes of Health Stroke Scale (NIHSS) scores (median 1\u00a0vs. 3,\n p<\/jats:italic>\n < 0.001) and reduced prevalence of atrial fibrillation (2.7%\u00a0vs. 12.5%), intracranial artery stenosis (ICAS; 48.1%\u00a0vs. 76.6%), and early neurological deterioration (24.6%\u00a0vs. 56.3%; all\n p<\/jats:italic>\n < 0.05). The 90\u2010day poor prognosis rate was significantly lower in PTI (4.8%\u00a0vs. 20.3%,\n p<\/jats:italic>\n < 0.001), whereas 1\u2010year MACE rates did not differ between groups (12.3%\u00a0vs. 15.6%,\n p<\/jats:italic>\n = 0.497). Among PTI cases, territorial distributions comprised inferolateral (80.2%), tuberothalamic (13.4%), paramedian (including Percheron artery, 5.9%), and posterior choroidal arteries (0.5%). Tuberothalamic artery infarctions exhibited higher cognitive impairment rates (36.0%) than other subgroups. Multivariate analysis identified baseline NIHSS as an independent predictor of 90\u2010day poor prognosis (OR = 1.634, 95% CI 1.152\u20132.320,\n p<\/jats:italic>\n = 0.006), while ICAS was associated with 1\u2010year MACE (OR = 3.908; 95% CI, 1.188\u201312.849;\n p<\/jats:italic>\n = 0.025) in PTI patients.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n PTI presented favorable short\u2010term outcomes, consistent with initial stroke severity, yet carried a 12.3% annual MACE risk, particularly in patients with coexisting ICAS. These findings underscore the importance of addressing intracranial stenosis in secondary prevention strategies for CSVD.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/brb3.71755","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:31:21Z","timestamp":1790659881000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Natural History and Factors Influencing 90\u2010Day Clinical Outcomes and 1\u2010Year Recurrence of Thalamic Stroke"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4750-9766","authenticated-orcid":false,"given":"Huang","family":"Qiang","sequence":"first","affiliation":[{"name":"Department of Neurology, Beijing Friendship Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui","family":"Ying","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Friendship Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Yongbo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Friendship Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/17474930231218817"},{"key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/S1474-4422(21)00024-7","article-title":"Development of Imaging\u2010Based Risk Scores for Prediction of Intracranial Haemorrhage and Ischaemic Stroke in Patients Taking Antithrombotic Therapy After Ischaemic Stroke or Transient Ischaemic Attack: A Pooled Analysis of Individual Patient Data From Cohort Studies","volume":"20","author":"Best J. 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