{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:02:04Z","timestamp":1790326924804,"version":"4.1.0"},"reference-count":60,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171465"],"award-info":[{"award-number":["82171465"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study aimed to examine the interplay among depressive symptoms, cognitive impairment, and dysfunction after ischemic stroke using a network analysis approach, and to investigate whether selected network\u2010derived targets show convergent neuroanatomical correlates using voxel\u2010based lesion\u2013symptom mapping (VLSM) in an imaging subset.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We prospectively enrolled 589 acute ischemic stroke patients and constructed a 3\u2010month post\u2010stroke symptom network. Depression, cognition, and dysfunction were assessed via 17\u2010item Hamilton Depression Rating Scale (HDRS), Mini\u2010Mental State Examination (MMSE), and modified Rankin Scale (mRS), respectively. Flow analysis quantified dysfunction's direct association with neuropsychiatric symptoms. In an imaging subset (\n                      <jats:italic>n<\/jats:italic>\n                      = 429), VLSM localized neuroanatomical substrates of key network targets.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Depressed mood\u00a0<\/jats:italic>\n                      and\n                      <jats:italic>\u00a0Psychiatric anxiety\u00a0<\/jats:italic>\n                      were central symptoms, while\n                      <jats:italic>Suicidality, Loss of interest,\u00a0Psychiatric anxiety<\/jats:italic>\n                      , and\n                      <jats:italic>\u00a0mRS score<\/jats:italic>\n                      acted as bridge symptoms\n                      <jats:italic>.\u00a0mRS\u00a0score<\/jats:italic>\n                      was positively associated with\n                      <jats:italic>\u00a0Suicidality and Loss of interest<\/jats:italic>\n                      , and negatively associated with\n                      <jats:italic>Language<\/jats:italic>\n                      . VLSM identified a significant cluster in the left superior corona radiata for\n                      <jats:italic>\u00a0Language<\/jats:italic>\n                      , whereas\n                      <jats:italic>\u00a0Suicidality\u00a0<\/jats:italic>\n                      and\n                      <jats:italic>\u00a0Loss of interest<\/jats:italic>\n                      \u00a0showed no focal anatomical correlates.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Identifying core and bridge symptoms (e.g.,\n                      <jats:italic>Depressed mood<\/jats:italic>\n                      ,\n                      <jats:italic>Psychiatric anxiety<\/jats:italic>\n                      ,\n                      <jats:italic>Suicidality<\/jats:italic>\n                      ,\n                      <jats:italic>Loss of interest<\/jats:italic>\n                      ,\n                      <jats:italic>mRS score<\/jats:italic>\n                      ) may serve as candidate indicators for rehabilitation planning.\n                      <jats:italic>Suicidality<\/jats:italic>\n                      ,\n                      <jats:italic>Loss of interest<\/jats:italic>\n                      and\n                      <jats:italic>Language<\/jats:italic>\n                      may serve as promising candidates for monitoring and rehabilitation. Notably, while\n                      <jats:italic>Language<\/jats:italic>\n                      maps to the left superior corona radiata, the absence of focal lesions for\n                      <jats:italic>Suicidality<\/jats:italic>\n                      and\n                      <jats:italic>Loss of interest<\/jats:italic>\n                      suggests reliance on distributed network dysfunction.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71759","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T06:42:10Z","timestamp":1789108930000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Symptom Network and Lesion Mapping of Post\u2010Stroke Depression, Cognitive Impairment, and Dysfunction: A Multicenter Cohort Study"],"prefix":"10.1002","volume":"16","author":[{"given":"Qing","family":"Du","sequence":"first","affiliation":[{"name":"Department of Neurology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chensheng","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei 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