{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:02:19Z","timestamp":1790326939816,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Depression in type 2 diabetes mellitus (T2DM) hinders self\u2010management and glycemic control. Behavioral activation (BA), by increasing participation in positive activities, holds promise for simultaneously improving depressive symptoms and diabetes outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study evaluated the effects of BA or BA\u2010based interventions on depressive symptoms, glycated hemoglobin (HbA1c), diabetes self\u2010efficacy, and self\u2010management behaviors in adults with T2DM, and summarized their implementation characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>PubMed, Web of Science, Embase, Cochrane Library, PsycINFO, CNKI, VIP, and Wanfang Data were searched from inception to February 1, 2026. Interventional studies assessing BA or BA\u2010based interventions in adults with T2DM and reporting at least one prespecified outcome were included. Quantitative meta\u2010analyses were restricted to randomized controlled trials (RCTs) and conducted using random\u2010effects models. Implementation characteristics from all included studies were narratively synthesized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Six studies involving 252 participants met the inclusion criteria, including five RCTs and one single\u2010arm pre\u2010post study. The meta\u2010analysis suggested a reduction in depressive symptoms (SMD = \u22120.81, 95% CI: \u22121.22 to \u20100.41,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), but no statistically significant effects on HbA1c (MD = \u22120.04%, 95% CI: \u22120.30 to 0.22,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.76), diabetes self\u2010efficacy (SMD = 0.03, 95% CI: \u22120.30 to 0.35,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.87), or self\u2010management behaviors (SMD = 0.04, 95% CI: \u22120.23 to 0.32,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.77). Narrative synthesis indicated that BA interventions varied in delivery format, dosage, provider background, and integration with diabetes\u2010specific content. Most interventions were delivered by non\u2010mental health professionals and incorporated core BA components such as activity monitoring and goal setting.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>BA may reduce depressive symptoms in adults with T2DM, whereas its effects on glycemic control, diabetes self\u2010efficacy, and self\u2010management behaviors remain uncertain. BA has been delivered in flexible formats and may have potential for integration into diabetes care, but larger, well\u2010powered RCTs with longer follow\u2010up are needed to determine whether diabetes\u2010specific BA can improve behavioral and physiological outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71761","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T07:11:01Z","timestamp":1789456261000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Behavioral Activation for Depression and Glycemic Control in Type 2 Diabetes: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"16","author":[{"given":"Xiao","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Nursing Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology Wuhan China"},{"name":"School of Nursing Tongji Medical 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