{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:02:17Z","timestamp":1790326937817,"version":"4.1.0"},"reference-count":66,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1145142"],"award-info":[{"award-number":["GNT1145142"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Vertical sleeve gastrectomy (VSG) is widely recognized as an effective metabolic surgery for achieving durable weight loss and improving obesity\u2010related comorbidities. However, some patients experience deteriorating mental health post\u2010surgery, prompting investigation into underlying mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study examined diet\u2010induced obese C57BL\/6J male mice that underwent either VSG or sham surgery, as well as a cohort of high\u2010fat diet\u2010fed male mice subsequently transitioned to a low\u2010fat diet (LFD), compared to chow\u2010fed controls. We assessed metabolic parameters (body weight, food intake, glucose tolerance, and body composition), interscapular temperature, a proxy measure of thermogenic activity via transponder\u2010monitored activity and temperature in brown and white adipose tissue and behavioral outcomes related to hedonic processing, anxiety\u2010like behavior, motivation, and cognitive flexibility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>VSG produced rapid and sustained reductions in body weight, transient decreases in food intake, reduced adiposity, trends toward improved glucose regulation, and increased interscapular adipose tissue temperature, suggesting increased brown adipose tissue thermogenic activity. Preferences for sucrose and saccharin remained unchanged in the low\u2010fat diet\u2010fed cohort. VSG reduced responding to rewards under high\u2010fat diet conditions, an effect not observed in a separate cohort of mice transitioned to a LFD post\u2010surgery but did not significantly enhance cognitive flexibility. In contrast, sham\u2010operated low\u2010fat diet\u2010fed mice demonstrated improved cognitive flexibility. Anxiety\u2010like behaviors were unaffected by VSG.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings confirm the robust metabolic benefits of VSG. Exploratory comparisons between independent dietary cohorts suggest that dietary context may influence reward\u2010related and cognitive outcomes following VSG. However, these findings are based on comparisons between separate dietary cohorts and should be interpreted cautiously. Further studies are required to determine whether dietary context contributes to long\u2010term behavioral outcomes following VSG.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71766","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T06:49:56Z","timestamp":1789454996000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Impact of Vertical Sleeve Gastrectomy on Behavioral and Reward\u2010Related Outcomes"],"prefix":"10.1002","volume":"16","author":[{"given":"Jayasinghe","family":"R","sequence":"first","affiliation":[{"name":"Department of Physiology Monash University Clayton VIC Australia"},{"name":"Biomedicine Discovery Institute Monash University Clayton VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotrowski","family":"J","sequence":"additional","affiliation":[{"name":"Department of Physiology Monash University Clayton VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greaves","family":"E","sequence":"additional","affiliation":[{"name":"Department of Physiology Monash University Clayton VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lemus","family":"MB","sequence":"additional","affiliation":[{"name":"Department of Physiology Monash University Clayton VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reed","family":"F","sequence":"additional","affiliation":[{"name":"Department of Physiology Monash University Clayton VIC Australia"},{"name":"Biomedicine Discovery Institute Monash University Clayton VIC Australia"},{"name":"Australian Eating Disorders Research &amp; 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