{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T10:34:52Z","timestamp":1792924492711,"version":"4.5.0"},"reference-count":54,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Glycyrrhizic acid (Gly\u2010A) exhibits anti\u2010inflammatory and antioxidant effects in various central nervous system disorders. Acute fatigue and chronic fatigue (CF) are associated with serious physical and psychological effects. However, the underlying pathophysiology and effective therapeutic strategies for these conditions remain poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study aims to evaluate the therapeutic potential of Gly\u2010A against fatigue, and to elucidate the underlying mechanisms of its action.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We established a mouse model of acute exercise\u2010induced fatigue and evaluated fatigue\u2010related indices. To identify specific pathways involved in Gly\u2010A's therapeutic effects, we employed RNA sequencing, network pharmacology, and in vitro oxygen\u2010deficit models, aiming to clarify the mechanisms. Additionally, we established a mouse model of CF to compare the therapeutic efficacy of Gly\u2010A with positive control drugs by assessing identical parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Gly\u2010A significantly improved fatigue\u2010related indices without affecting body weight. RNA sequencing and network pharmacology analyses showed that Gly\u2010A modulates oxidative stress responses and targets the NF\u2010\u03baB (nuclear factor\u2010kappa B)\/NLRP3 (NOD\u2010like receptor thermal protein domain associated protein 3) signaling and apoptotic pathways. In the CF mouse model, oral administration of Gly\u2010A significantly increased motor activity, alleviated anxiety and depression, and improved neurocognitive function compared to model mice, exhibiting superior efficacy to positive control drugs. These findings suggest that Gly\u2010A exerts anti\u2010inflammatory effects by targeting the NF\u2010\u03baB\/NLRP3 signaling pathway, thereby reducing neuronal apoptosis in CF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Gly\u2010A exhibits therapeutic potential against acute exercise\u2010fatigue and CF, primarily by attenuating apoptosis through the inhibition of the NF\u2010\u03baB\/NLRP3 signaling pathway.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71773","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T05:01:07Z","timestamp":1790571667000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Glycyrrhizic Acid Relieves Fatigue Induced by Acute and Chronic\u00a0Exercise in Mice via Inhibition of the NF\u2010\u03baB\/NLRP3 Signaling Pathway"],"prefix":"10.1002","volume":"16","author":[{"given":"Xin\u2010ying","family":"Cai","sequence":"first","affiliation":[{"name":"School of Medicine Xiamen University Xiamen People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010jun","family":"Li","sequence":"additional","affiliation":[{"name":"School of Medicine Xiamen University Xiamen People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cai\u2010xia","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Medicine Xiamen University Xiamen People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Peng","sequence":"additional","affiliation":[{"name":"School of Medicine Xiamen University Xiamen People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010chao","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Medicine 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