{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:02:11Z","timestamp":1790326931819,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,9]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background and Objectives<\/jats:title>\n Delta\u20109\u2010tetrahydrocannabinol (THC), the psychoactive constituent of cannabis, continues to be critically evaluated for its potential therapeutic efficacy and associated safety concerns in major depressive disorder (MDD). Length of stay and readmission rates are key indicators of treatment response and prognosis. With rising cannabis use, understanding the effects of THC is essential. The objective of this study is to evaluate THC's impact on 30\u2010day readmission and length of stay among inpatient MDD individuals at an academic hospital.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A single\u2010center retrospective chart review evaluated adult patients admitted for MDD between August 2018 and May 2025. Patients were categorized by positive or negative THC urine drug screen on admission. The primary outcomes were 30\u2010day psychiatric readmission and hospital length of stay. Unadjusted and adjusted analyses were performed. Logistic regression was used to evaluate 30\u2010day readmission, and multiple linear regression was used to evaluate length of stay. Adjusted models included age, gender at birth, psychiatric comorbidities, and polysubstance use.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among 743 cases, 211 (28.4%) were THC positive. A THC\u2010positive urine drug screen was not independently associated with 30\u2010day psychiatric readmission (adjusted odds ratio [OR]: 0.821; 95% CI 0.319\u20132.115;\n p<\/jats:italic>\n \u00a0=\u00a00.683) or difference in hospital length of stay (mean difference \u22120.242 days; 95% CI \u22120.983 to 0.499;\n p<\/jats:italic>\n \u00a0=\u00a00.521). Older age was associated with longer length of stay, while female gender at birth was associated with shorter length of stay.\n <\/jats:p>\n <\/jats:sec>\n \n Discussion and Conclusions<\/jats:title>\n THC\u2010positive urine drug screens were not independently associated with 30\u2010day psychiatric readmission or differences in hospital length of stay among patients hospitalized for MDD. Larger studies are needed to further evaluate the relationship between cannabis use and psychiatric hospitalization outcomes.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/brb3.71792","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:54:23Z","timestamp":1790229263000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparing the Impact of Tetrahydrocannabinol on 30\u2010Day Readmission Rates and Hospital Length of Stay in Patients With Depression"],"prefix":"10.1002","volume":"16","author":[{"given":"Mohammed E.","family":"Khedr","sequence":"first","affiliation":[{"name":"Ernest Mario School of Pharmacy Piscataway New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunjin","family":"Lee","sequence":"additional","affiliation":[{"name":"Ernest Mario School of Pharmacy Piscataway New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammed A.","family":"Mirza","sequence":"additional","affiliation":[{"name":"Ernest Mario School of Pharmacy Piscataway New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humberto","family":"Jimenez","sequence":"additional","affiliation":[{"name":"Ernest Mario School of Pharmacy Piscataway New Jersey USA"},{"name":"St. Joseph's University Medical Center Paterson New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9997-3715","authenticated-orcid":false,"given":"Daniel","family":"Greer","sequence":"additional","affiliation":[{"name":"Ernest Mario School of Pharmacy Piscataway New Jersey USA"},{"name":"St. Joseph's University Medical Center Paterson New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"StatPearls","author":"Bains N.","year":"2025"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23105526"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291724003143"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2018.04.054"},{"key":"e_1_2_11_6_1","volume-title":"StatPearls","author":"Dhaliwal J. S.","year":"2025"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/ADM.0000000000001197"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.625158"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291713001438"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2020.05.028"},{"key":"e_1_2_11_11_1","unstructured":"National Alliance on Mental Illness. n.d. \u201cMental Health by the Numbers.\u201d Accessed May 14 2026.https:\/\/www.nami.org\/mental\u2010health\u2010by\u2010the\u2010numbers\/."},{"key":"e_1_2_11_12_1","unstructured":"National Institute of Mental Health. n.d. \u201cMajor Depression.\u201d Accessed June 20 2025.https:\/\/www.nimh.nih.gov\/health\/statistics\/major\u2010depression."},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.12.043"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2021.04.024"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010022\u201001937\u20107"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.71792","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/brb3.71792","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.71792","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T08:11:54Z","timestamp":1790323914000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.71792"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":14,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/brb3.71792"],"URL":"https:\/\/doi.org\/10.1002\/brb3.71792","archive":["Portico"],"relation":{},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-06-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71792"}}