{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:52:12Z","timestamp":1791345132096,"version":"4.3.1"},"reference-count":51,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To describe the distribution patterns and cross\u2010study heterogeneity of depressive symptom trajectories in older adults and to identify consistent predictors of high\u2010symptom trajectories for targeted intervention strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Following PRISMA 2020 guidelines, six databases were searched from April 2010 to January 2026 for longitudinal studies using latent variable mixture models in adults aged \u2265\u00a060 years. Study quality was assessed using the Newcastle\u2013Ottawa Scale. Descriptive synthesis was employed due to methodological heterogeneity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010one studies (median\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a03428; 26 observations after accounting for within\u2010study stratification by sex, poverty status, and country) met inclusion criteria. High\u2010symptom trajectories were identified in 18 of 21 studies (0%\u201342.2%). Low\u2010symptom trajectories predominated (12.4%\u201384.5%). Consistent risk factors included female sex, functional limitations, and multimorbidity. Higher educational attainment was the most consistent protective factor.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Older adults exhibit heterogeneous depressive symptom trajectories, with clinically significant high\u2010symptom subgroups universally present but context\u2010dependent. Modifiable predictors provide evidence for precision prevention strategies. Because estimates are descriptive and derived from heterogeneous instruments, they should be interpreted as heuristic indicative ranges rather than precise global benchmarks. Standardized assessment protocols are needed to enable quantitative synthesis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71793","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:44:46Z","timestamp":1791344686000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence and Predictors of Depressive Symptom Trajectories in Older Adults: A Systematic Review"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5708-3165","authenticated-orcid":false,"given":"Yuying","family":"Li","sequence":"first","affiliation":[{"name":"Department of Nursing Changchun University of Chinese Medicine  Changchun Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nursing Changchun University of Chinese Medicine  Changchun Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5874-3451","authenticated-orcid":false,"given":"Xue","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Nursing Changchun University of Chinese Medicine  Changchun Jilin 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