{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:03:19Z","timestamp":1790661799593,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["2025GXNSFAA069411"],"award-info":[{"award-number":["2025GXNSFAA069411"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Speech impairment is common in Parkinson's disease (PD) and lacks effective clinical interventions due to poorly understood underlying mechanisms. Therefore, this study aimed to explore the relationship between altered brain functional networks and speech impairments in PD, identifying neural correlates of abnormal brain activity linked to PD\u2010related speech disorders (SD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Baseline clinical characteristics, neurobehavioral assessments, and resting\u2010state functional magnetic resonance imaging (rs\u2010fMRI) data were collected from three groups: PD individuals with SD (PD\u2010SD group), PD individuals without SD (PD\u2010NON\u2010SD group), and healthy controls (HC group). Independent component analysis (ICA) was performed to identify resting\u2010state networks (RSNs) using the Group ICA of fMRI Toolbox (GIFT) implemented in MATLAB. Functional network connectivity (FNC) was subsequently quantified by calculating Pearson correlation coefficients between the extracted RSNs. One\u2010way analysis of variance (ANOVA) was used to assess group differences in FNC, followed by post hoc pairwise comparisons for networks showing significant effects. Given the reported association between speech impairment and cognitive impairment in PD, correlation analyses were further performed to investigate the relationships between FNC alterations and clinical measures, including speech performance and cognitive function assessed by the Montreal Cognitive Assessment (MoCA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Significant differences in FNC were observed between the left frontoparietal network (LFPN) and auditory network (AUN) across the three groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0280). In particular, the FNC between LFPN and AUN was significantly stronger in the PD\u2010SD group compared to the PD\u2010NON\u2010SD group (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0221) and the HC group (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0047). Spearman correlation analysis revealed significant positive correlation between LFPN\u2010AUN functional connectivity and Unified Parkinson's Disease Rating Scale part III (UPDRS\u2010III) speech subscores (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sub>s<\/jats:sub>\n                      \u00a0=\u00a00.2624,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0466), as well as a significant negative correlation with MoCA scores (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sub>s<\/jats:sub>\n                      \u00a0=\u00a0\u22120.2847,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0249).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study identifies disrupted functional connectivity between the LFPN and AUN in individuals with PD\u2010SD. These findings suggest that altered integration of RSNs involved in motor, cognitive, and auditory processing may contribute to speech impairment in PD. Hyperconnectivity between LFPN and AUN may thus serve as a neural substrate for speech impairment in PD. Specifically, increased connectivity between the LFPN and AUN may represent a neural signature associated with speech dysfunction in PD. These results provide potential mechanistic insights and highlight candidate neural targets for future neuromodulation strategies aimed at improving speech function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71798","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:45:12Z","timestamp":1790660712000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Altered Inter\u2010Network Functional Integration Underlies Speech Impairment in Parkinson's Disease: A Resting\u2010State fMRI Analysis"],"prefix":"10.1002","volume":"16","author":[{"given":"Shan","family":"Deng","sequence":"first","affiliation":[{"name":"Department of Neurology Liuzhou Workers' Hospital  Liuzhou Guangxi China"},{"name":"Department of Neurology The First Affiliated Hospital of Guangxi Medical University  Nanning Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqing","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Neurology Liuzhou Workers' Hospital  Liuzhou Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zimei","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Neurology People's Hospital of Chuxiong Yi Autonomous Prefecture  Chuxiong Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cai","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Neurology Minzu Hospital of Guangxi Zhuang Autonomous Region  Nanning Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Neurology Liuzhou Workers' Hospital  Liuzhou Guangxi 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