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The impact of these genetic alterations on overall survival (OS<\/jats:styled-content>) and progression free survival (PFS<\/jats:styled-content>) was evaluated.<\/jats:p><\/jats:sec>Methods<\/jats:title>A cohort of 80 patients surgically treated at Hospital Cl\u00ednico San Carlos, Madrid, between March 2004 and November 2012, was analyzed. Tumors were distributed in 73 primary brain tumors (gliomas, meningiomas, hemangiopericytomas and hemangioblastomas) and seven secondary tumors evolved from a low grade glioma, thus providing a mixed sample.<\/jats:p><\/jats:sec>Results<\/jats:title>IDH<\/jats:styled-content>1<\/jats:italic>R132H<\/jats:italic><\/jats:sup> gene mutation was found in 12 patients (15%) and appears more frequently in secondary tumors (5 (71.4%) whereas in 7 (9.7%) primary tumors (p<\/jats:italic>\u00a0<\u00a0.001)). The mutation is related to WHO<\/jats:styled-content> grade II<\/jats:styled-content> in primary tumors and a supratentorial location in secondary tumors. The OS<\/jats:styled-content> analysis for IDH<\/jats:styled-content>1<\/jats:italic> showed a tendency towards a better prognosis of the tumors containing the mutation (p<\/jats:italic>\u00a0=\u00a0.059).The IDH<\/jats:styled-content>1<\/jats:italic>R132H<\/jats:italic><\/jats:sup> mutation confers a better PFS<\/jats:styled-content> (p<\/jats:italic>\u00a0=\u00a0.025) on primary tumors. The T allele of VEFG<\/jats:styled-content><\/jats:italic> +936 C\/T polymorphism was found in 16 patients (20%). No relation was found between this polymorphism and primary or secondary tumor, neither with OS<\/jats:styled-content> or PFS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>IDH<\/jats:styled-content>1<\/jats:italic>R132H<\/jats:italic><\/jats:sup> gene mutation is exclusive in supratentorial tumors and more frequent in secondary ones, with a greater survival trend and better PFS<\/jats:styled-content> in patients who carry it. The T allele of VEGF<\/jats:styled-content><\/jats:italic> +936 C\/T polymorphism is more common in primary tumors, although there is no statistical relation with survival.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.718","type":"journal-article","created":{"date-parts":[[2017,8,2]],"date-time":"2017-08-02T09:34:55Z","timestamp":1501666495000},"source":"Crossref","is-referenced-by-count":7,"title":["Genetic alterations of IDH<\/scp>1 and Vegf in brain tumors"],"prefix":"10.1002","volume":"7","author":[{"given":"Silvia","family":"Veganzones","sequence":"first","affiliation":[{"name":"Department of Clinical Analysis Hospital Cl\u00ednico San Carlos and Hospital Universitario Puerta de Hierro\u2010Majadahonda Majadahonda Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia","family":"de la Orden","sequence":"additional","affiliation":[{"name":"Department of Clinical Analysis Hospital Cl\u00ednico San Carlos and Hospital Universitario Puerta de 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