{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:47:18Z","timestamp":1792043238304,"version":"4.4.0"},"reference-count":59,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the effect of Naoxueshu Oral Liquid on rats with radiation\u2010induced brain injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 108 male Sprague\u2013Dawley rats were randomly assigned to a control group, an irradiated + normal saline group (RBI+NS), and an irradiated + Naoxueshu Oral Liquid group (RBI+NXS). A radiation\u2010induced brain injury model was established by single\u2010dose whole\u2010brain high\u2010energy X\u2010ray irradiation (30\u00a0Gy). After irradiation, rats received Naoxueshu Oral Liquid (0.5\u00a0mL\/100\u00a0g\/day, gavage) or normal saline for 14 days. Body weight was monitored, cerebral edema was assessed by brain tissue water content on Days 3, 7, and 14, histopathology was evaluated by hematoxylin\u2013eosin (H&amp;E) staining, and Morris water maze training was conducted from Day 8 to Day 13 post\u2010irradiation, followed by the probe trial on Day 14 post\u2010irradiation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Body weight differed significantly among groups after irradiation (Day 3\/6\/9\/12: all\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01). Specifically, at Day 12, body weight was 328.17\u00b120.10\u00a0g (control), 258.50\u00b118.87\u00a0g (RBI+NS), and 302.83 \u00b1 10.87\u00a0g (RBI+NXS); RBI+NXS was higher than RBI+NS (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01), while control versus RBI+NS remained different (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01). H&amp;E staining showed widened perineuronal and perivascular spaces after irradiation, which were attenuated by Naoxueshu. In the Morris water maze, RBI+NS rats exhibited prolonged latency and fewer platform crossings; these impairments were improved after Naoxueshu treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Naoxueshu Oral Liquid reduced cerebral edema and improved Morris water maze performance in rats after whole\u2010brain irradiation. Because behavioral outcomes were assessed only using the Morris water maze, the cognitive\u2010related findings should be interpreted cautiously.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71801","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:07:03Z","timestamp":1792040823000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Naoxueshu Oral Liquid Attenuates Early Radiation\u2010Induced Brain Injury in Rats"],"prefix":"10.1002","volume":"16","author":[{"given":"Fuguang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurosurgery The First Affiliated Hospital of Henan Medical University; Henan medical Key Laboratory of Neurology, Henan Joint International Laboratory of Neurorestoratology for Senile Dementia, Henan Engineering Technology Research Center of Neurorestoratology ,Henan Engineering Laboratory of Neurorestoratology,Henan Key Laboratory of Neurorestoratology and Protein modification, First Affiliated Hospital of Henan Medical University, Xinxiang, Henan, 453100, China. Xinxiang City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The First Affiliated Hospital of Henan Medical University; Henan medical Key Laboratory of Neurology, Henan Joint International Laboratory of Neurorestoratology for Senile Dementia, Henan Engineering Technology Research Center of Neurorestoratology ,Henan Engineering Laboratory of Neurorestoratology,Henan Key Laboratory of Neurorestoratology and Protein modification, First Affiliated Hospital of Henan Medical University, Xinxiang, Henan, 453100, China. Xinxiang City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuiyuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The First Affiliated Hospital of Henan Medical University; Henan medical Key Laboratory of Neurology, Henan Joint International Laboratory of Neurorestoratology for Senile Dementia, Henan Engineering Technology Research Center of Neurorestoratology ,Henan Engineering Laboratory of Neurorestoratology,Henan Key Laboratory of Neurorestoratology and Protein modification, First Affiliated Hospital of Henan Medical University, Xinxiang, Henan, 453100, China. Xinxiang City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guosong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The First Affiliated Hospital of Henan Medical University; Henan medical Key Laboratory of Neurology, Henan Joint International Laboratory of Neurorestoratology for Senile Dementia, Henan Engineering Technology Research Center of Neurorestoratology ,Henan Engineering Laboratory of Neurorestoratology,Henan Key Laboratory of Neurorestoratology and Protein modification, First Affiliated Hospital of Henan Medical University, Xinxiang, Henan, 453100, China. Xinxiang City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shifang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The First Affiliated Hospital of Henan Medical University; Henan medical Key Laboratory of Neurology, Henan Joint International Laboratory of Neurorestoratology for Senile Dementia, Henan Engineering Technology Research Center of Neurorestoratology ,Henan Engineering Laboratory of Neurorestoratology,Henan Key Laboratory of Neurorestoratology and Protein modification, First Affiliated Hospital of Henan Medical University, Xinxiang, Henan, 453100, China. Xinxiang City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The First Affiliated Hospital of Henan Medical University; Henan medical Key Laboratory of Neurology, Henan Joint International Laboratory of Neurorestoratology for Senile Dementia, Henan Engineering Technology Research Center of Neurorestoratology ,Henan Engineering Laboratory of Neurorestoratology,Henan Key Laboratory of Neurorestoratology and Protein modification, First Affiliated Hospital of Henan Medical University, Xinxiang, Henan, 453100, China. Xinxiang City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The First Affiliated Hospital of Henan Medical University; Henan medical Key Laboratory of Neurology, Henan Joint International Laboratory of Neurorestoratology for Senile Dementia, Henan Engineering Technology Research Center of Neurorestoratology ,Henan Engineering Laboratory of Neurorestoratology,Henan Key Laboratory of Neurorestoratology and Protein modification, First Affiliated Hospital of Henan Medical University, Xinxiang, Henan, 453100, China. Xinxiang City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Hui","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The First Affiliated Hospital of Henan Medical University; Henan medical Key Laboratory of Neurology, Henan Joint International Laboratory of Neurorestoratology for Senile Dementia, Henan Engineering Technology Research Center of Neurorestoratology ,Henan Engineering Laboratory of Neurorestoratology,Henan Key Laboratory of Neurorestoratology and Protein modification, First Affiliated Hospital of Henan Medical University, Xinxiang, Henan, 453100, China. Xinxiang City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenchao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The First Affiliated Hospital of Henan Medical University; Henan medical Key Laboratory of Neurology, Henan Joint International Laboratory of Neurorestoratology for Senile Dementia, Henan Engineering Technology Research Center of Neurorestoratology ,Henan Engineering Laboratory of Neurorestoratology,Henan Key Laboratory of Neurorestoratology and Protein modification, First Affiliated Hospital of Henan Medical University, Xinxiang, Henan, 453100, China. Xinxiang City China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40644\u2010024\u201000736\u20101"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2020.105298"},{"issue":"11","key":"e_1_2_11_4_1","first-page":"58","article-title":"Effects of Naoxueshu Oral Liquid on Hemorheology, Homocysteine, and Vascular Endothelial Growth Factor in Patients With Cerebral Infarction","volume":"16","author":"Cao S. 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