{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T10:34:55Z","timestamp":1792924495077,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hearing loss (HL) has been increasingly implicated in Parkinson's disease (PD), but the epidemiological association between them and the underlying biological mechanisms remain unclear. This study aimed to investigate the association between HL and PD and to explore potential biological links between auditory deprivation and PD\u2010related pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data from the National Health and Nutrition Examination Survey (NHANES) and the China Health and Retirement Longitudinal Study (CHARLS) were analyzed using multivariable logistic regression, with sensitivity analyses performed in propensity score\u2010matched samples comprising 70 matched pairs in NHANES and 171 matched pairs in CHARLS. In parallel, an auditory\u2010deprivation model was established by ossicular chain interruption, while PD\u2010related pathology was modeled by MPTP administration once daily in three 7\u2010day treatment blocks (21 injections in total), with 48\u2010h drug\u2010free assessment intervals between blocks. Auditory deprivation was confirmed by auditory brainstem response. Motor function was assessed using the open field and rotarod tests, and dopaminergic neuron loss was evaluated by immunofluorescence. Striatal RNA sequencing, integrated with the GSE205450 dataset, was conducted to explore potential molecular mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Self\u2010reported hearing impairment was associated with higher odds of PD in both NHANES (OR, 1.79; 95% CI, 1.24\u20132.58) and CHARLS (OR, 1.42; 95% CI, 1.01\u20132.01). In propensity score\u2010matched analyses, the association remained significant in NHANES (70 matched pairs) and CHARLS (171 matched pairs). In animal experiments, significant HL \u00d7 MPTP interactions were observed for motor performance and TH\u2010positive dopaminergic neuron counts, with poorer outcomes in HL + MPTP mice than in MPTP\u2010only mice. Transcriptomic analysis identified Adcyap1 as a cross\u2010species candidate molecular link between auditory deprivation and PD\u2010related alterations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Self\u2010reported hearing impairment was associated with PD in the population\u2010based analyses, while experimental findings support a potential relationship between auditory deprivation and greater MPTP\u2010related motor and dopaminergic abnormalities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71806","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:08:06Z","timestamp":1792645686000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hearing Loss and Parkinson's Disease: Insights From Human and Animal Studies"],"prefix":"10.1002","volume":"16","author":[{"given":"Xiao","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Otolaryngology Institute of Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxin","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Otolaryngology Institute of Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Otolaryngology Institute of Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Otolaryngology Institute of Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Otolaryngology Institute of Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Communication Science and Disorders Dalhousie University  Halifax Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Otolaryngology Institute of Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shankai","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Otolaryngology Institute of Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.22360"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(21)00218\u2010X"},{"key":"e_1_2_13_4_1","first-page":"S87","article-title":"Parkinson's Disease: Health\u2010Related Quality of Life, Economic Cost, and Implications of Early Treatment","volume":"16","author":"Chen J. 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