{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T14:50:36Z","timestamp":1791471036659,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Adolescents with depressive, anxiety, and somatic symptom\u2010related disorders often present with overlapping symptom domains and functional difficulties, but cross\u2010sectional associations of Brief Resilience Scale (BRS) score with multidimensional symptom and functional burden in routine outpatient care remain insufficiently characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single\u2010center, real\u2010world, cross\u2010sectional study retrospectively analyzed routinely collected data from adolescents aged 12\u201318 years attending a psychological\/psychiatric outpatient clinic between January 2024 and December 2025. Eligible patients had clinician\u2010recorded depressive, anxiety, or somatic symptom\u2010related disorders and completed the BRS, PHQ\u20109, GAD\u20107, and PHQ\u201015. Associations of BRS score with symptom outcomes and predefined pragmatic functional\u2010burden indicators were assessed using multivariable linear, logistic, and negative binomial regression models; restricted cubic spline analyses were exploratory.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 522 screened adolescents, 447 were included. Across increasing BRS\u2010score quartiles, mean PHQ\u20109 scores ranged from 17.1 \u00b1 5.8 to 9.9 \u00b1 5.2, GAD\u20107 scores from 13.4 \u00b1 5.1 to 7.2 \u00b1 4.5, and PHQ\u201015 scores from 12.2 \u00b1 5.0 to 6.9 \u00b1 4.3. The predefined marked functional impairment indicator ranged from 71.4% in Q1 to 30.6% in Q4 (\n                      <jats:italic>P<\/jats:italic>\n                      for trend &lt;0.001). After adjustment, each 1\u2010SD higher BRS score was associated with lower PHQ\u20109 score (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      , \u22122.42; 95% CI, \u22123.02 to \u22121.82), GAD\u20107 score (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      , \u22121.84; 95% CI, \u22122.38 to \u22121.30), PHQ\u201015 score (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      , \u22121.50; 95% CI, \u22122.05 to \u22120.95), and functional impairment count (incidence rate ratio, 0.72; 95% CI, 0.64 to 0.82). Higher BRS score was also associated with lower odds of PHQ\u20109 score \u226510 (OR, 0.49; 95% CI, 0.36 to 0.66), GAD\u20107 score \u226510 (OR, 0.57; 95% CI, 0.43 to 0.75), PHQ\u201015 score \u226510 (OR, 0.61; 95% CI, 0.45 to 0.82), and marked functional impairment (OR, 0.53; 95% CI, 0.40 to 0.71). Exploratory spline analyses showed graded inverse associations but were not interpreted as identifying clinical thresholds.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Higher BRS score was concurrently associated with lower depressive, anxiety, and somatic symptom burden and fewer pragmatic indicators of functional burden in adolescent psychiatric outpatients. These cross\u2010sectional findings do not establish causality, prognostic utility, or treatment\u2010guiding value; longitudinal studies are needed to clarify temporal relationships and clinical utility.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71811","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T13:59:07Z","timestamp":1791467947000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["BRS\u2010Assessed Resilience, Symptom Burden, and Functional Burden in Adolescents With Depressive, Anxiety, or Somatic Symptom\u2010Related Disorders: A Single\u2010Center Real\u2010World Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7397-2500","authenticated-orcid":false,"given":"Longhuan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychology Harrison International Peace Hospital  Hengshui Hebei Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology Harrison International Peace Hospital  Hengshui Hebei Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology Harrison International Peace Hospital  Hengshui Hebei Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingcong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Abdominal Surgery The Second People's Hospital of Hengshui  Hengshui Hebei Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology Harrison International Peace Hospital  Hengshui Hebei Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Shan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology Harrison International Peace Hospital  Hengshui Hebei Province 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