{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T06:50:03Z","timestamp":1791528603397,"version":"4.3.4"},"reference-count":50,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["101043416"],"award-info":[{"award-number":["101043416"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","award":["R432\u20102023\u201094"],"award-info":[{"award-number":["R432\u20102023\u201094"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Purpose<\/jats:title>\n \n Moderate repeated hypoxia (MRH) has shown neuroprotective and neuroplastic effects, partly mediated by erythropoietin (EPO) via hypoxia\u2010inducible factors (HIFs). This study examined the effects of 3 weeks of daily 3.5\u2010h normobaric hypoxia (12% O\n 2<\/jats:sub>\n ) versus normoxia (20% O\n 2<\/jats:sub>\n ) combined with cognitive training on oxygen saturation (SpO\n 2<\/jats:sub>\n ), cerebral side effects, hematology (including EPO and brain\u2010derived neurotrophic factor [BDNF]), and cognitive learning. We also assessed SpO\n 2<\/jats:sub>\n associations with side effects, hematology, and learning outcomes, as well as potential clinical and demographic predictors of hypoxic response.\n <\/jats:p>\n <\/jats:sec>\n \n Method<\/jats:title>\n Data from 84 healthy participants (HP) and 24 participants with remitted mood disorders (MD) in the ongoing ALTIBRAIN trial (NCT06121206) were analyzed. HP were randomized to MRH or normoxia (with\/without cognitive training), while MD participants were randomized to MRH with cognitive training or treatment as usual.<\/jats:p>\n <\/jats:sec>\n \n Finding<\/jats:title>\n \n MRH reduced SpO\n 2<\/jats:sub>\n (97.5% \u00b1 1.0% to 85.9% \u00b1 2.9%,\n p<\/jats:italic>\n < 0.001), but this effect attenuated over time (\n p<\/jats:italic>\n < 0.001). Side effects (e.g., dizziness and headaches) were slightly higher in MRH (\n p<\/jats:italic>\n = 0.044) but declined over time (\n p<\/jats:italic>\n < 0.001). Reticulocyte, hemoglobin, and thrombocyte levels increased (\n p<\/jats:italic>\n \u2264 0.029), while EPO decreased (\n p<\/jats:italic>\n = 0.003) and BDNF remained unchanged (\n p<\/jats:italic>\n > 0.60). MRH slightly flattened cognitive learning curves (\n p<\/jats:italic>\n < 0.001). MD participants experienced marginally higher side effects (\n p<\/jats:italic>\n = 0.006), but overall tolerability was good.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n MRH was safe and well\u2010tolerated, influencing SpO\n 2<\/jats:sub>\n , hematology, and learning curves. If future research confirms cognitive and neuroplastic benefits, MRH with cognitive training could be a promising treatment for cognitive impairment.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/brb3.71812","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T06:01:04Z","timestamp":1791525664000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring Associations Between Hypoxia, Serum Erythropoietin, and Cognition in Patients With Mood Disorders and Healthy Individuals"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3761-0420","authenticated-orcid":false,"given":"Barbara Emilie Rotb\u00f8l","family":"\u00d8rum","sequence":"first","affiliation":[{"name":"Neurocognition and Emotion Across Disorders of the Brain (NEAD) Centre, Psychiatric Centre Copenhagen Frederiksberg Hospital Frederiksberg Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6632-5025","authenticated-orcid":false,"given":"Johanna Mariegaard","family":"Schandorff","sequence":"additional","affiliation":[{"name":"Neurocognition and Emotion Across Disorders of the Brain (NEAD) Centre, Psychiatric Centre Copenhagen Frederiksberg Hospital Frederiksberg Denmark"},{"name":"Department of Psychology University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4257-3136","authenticated-orcid":false,"given":"Viktoria","family":"Damgaard","sequence":"additional","affiliation":[{"name":"Neurocognition and Emotion Across Disorders of the Brain (NEAD) Centre, Psychiatric Centre Copenhagen Frederiksberg Hospital Frederiksberg Denmark"},{"name":"Department of Psychology University of Copenhagen Copenhagen 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Frederiksberg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1321-8901","authenticated-orcid":false,"given":"Martin Balslev","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine University of Copenhagen Copenhagen Denmark"},{"name":"Centre For Affective Disorders Research (CADIC), Psychiatric Centre Copenhagen Frederiksberg Hospital Frederiksberg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2572-1384","authenticated-orcid":false,"given":"Kamilla Woznica","family":"Miskowiak","sequence":"additional","affiliation":[{"name":"Neurocognition and Emotion Across Disorders of the Brain (NEAD) Centre, Psychiatric Centre Copenhagen Frederiksberg Hospital Frederiksberg Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen Copenhagen 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