{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T06:51:00Z","timestamp":1791528660338,"version":"4.3.4"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001366"],"award-info":[{"award-number":["82001366"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2022KY506"],"award-info":[{"award-number":["2022KY506"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2024KY025"],"award-info":[{"award-number":["2024KY025"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Ocular myasthenia gravis (OMG) is an autoantibody\u2010mediated disease characterized by extraocular muscle weakness. Telitacicept has shown potential in treating autoimmune diseases, but its efficacy and corticosteroid\u2010tapering outcomes in OMG remain unexamined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective, multicenter study evaluated the efficacy and corticosteroid\u2010tapering outcomes of telitacicept in 19 OMG patients (11 with refractory OMG and eight with newly\/reinitiated treatment OMG). The primary endpoint was the proportion of patients achieving minimal symptom expression (MSE) within 6 months. Secondary endpoints included changes in Myasthenia Gravis Activities of Daily Living (MG\u2010ADL) scores and reductions in daily prednisone dosage, cumulative response rate (CRR), and short\u2010term tolerability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Following 6 months of telitacicept treatment, 68.42% of the overall cohort achieved MSE, with the median MG\u2010ADL score significantly decreasing from 3.00 to 0.00 (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.0001). Daily prednisone dosage substantially decreased: the median daily prednisone dose fell from 20.00 to 5.00\u00a0mg (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.0001), and 84.21% of patients received prednisone at \u22645\u00a0mg\/day at month 6. All patients met the predefined initial response criterion within 5 weeks. The refractory and newly\/reinitiated treatment groups achieved final MSE rates of 72.7% and 62.5%, respectively, and both groups showed significant reductions in prednisone dependence. This cohort had no serious adverse events.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this exploratory cohort, telitacicept\u2010based therapy may represent a promising option for OMG, with favorable clinical outcomes, substantial prednisone dose reduction, and acceptable short\u2010term tolerability in patients with different prior treatment histories. Further prospective controlled studies are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71816","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T06:30:47Z","timestamp":1791527447000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real\u2010World Clinical Outcomes and Corticosteroid Tapering in Telitacicept\u2010Based Therapy for Ocular Myasthenia Gravis: An Exploratory Analysis by Prior Treatment History"],"prefix":"10.1002","volume":"16","author":[{"given":"Siyu","family":"Xie","sequence":"first","affiliation":[{"name":"The Second Clinical Medical College of Hangzhou Normal University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenli","family":"Song","sequence":"additional","affiliation":[{"name":"Center For Rehabilitation Medicine, Department of Neurology Zhejiang Provincial People's Hospital (Affiliated 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