{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:00:14Z","timestamp":1790830814975,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Early detection of neurocognitive disorders is crucial for timely intervention in older adults. The Six\u2010Item Cognitive Impairment Test (6\u2010CIT) is a brief screening tool designed for rapid cognitive assessment, but a validated Persian version has not been available to date. This study aimed to translate, culturally adapt, and psychometrically evaluate the Persian version of the 6\u2010CIT among Iranian older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this prospective cross\u2010sectional psychometric validation and diagnostic accuracy study, 180 participants aged \u2265 60 years were recruited from outpatient geriatric clinics and categorized into three equal groups: normal cognition, Mild Cognitive Impairment (MCI), and dementia. Diagnoses were established by a geriatric psychiatrist using DSM\u20105 criteria, and severity was staged using the Clinical Dementia Rating (CDR) criteria. Reliability was assessed through internal consistency (Cronbach's\n                      <jats:italic>\u03b1<\/jats:italic>\n                      ) and test\u2013retest stability (intraclass correlation coefficient, ICC 3,1). Validity was examined via convergent validity with the Mini\u2010Mental State Examination (MMSE) and exploratory principal component analysis (PCA). Diagnostic accuracy, sensitivity, and specificity were evaluated using receiver operating characteristic (ROC) analysis and Youden's J index.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The Persian 6\u2010CIT demonstrated good internal consistency (Cronbach's\n                      <jats:italic>\u03b1<\/jats:italic>\n                      = 0.836) and strong test\u2013retest reliability (ICC = 0.849). A strong negative correlation with the MMSE supported convergent validity (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      = \u20130.919,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). PCA supported a unidimensional structure explaining 71.72% of the total variance. ROC analysis for dementia yielded an AUC of 0.984 (95% CI: 0.961\u20131.000); a cutoff score of \u2265 11 provided 96.7% sensitivity and 85.8% specificity, while a cutoff of \u2265 14 maximized overall mathematical accuracy (93.3% sensitivity, 94.2% specificity). Furthermore, diagnostic accuracy for MCI was also high (AUC = 0.976, 95% CI: 0.947\u20130.997), with an optimal cutoff of \u2265 2 yielding 96.7% sensitivity and 96.7% specificity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The Persian 6\u2010CIT is a brief, reliable, and valid instrument for screening both MCI and dementia among Iranian older adults in specialized outpatient settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71818","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:46:16Z","timestamp":1790829976000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reliability, Validity, and Diagnostic Accuracy of the Persian Six\u2010Item Cognitive Impairment Test (6\u2010CIT) in Older Adult Outpatients"],"prefix":"10.1002","volume":"16","author":[{"given":"Seyed Mohammad Mahdi","family":"Sadeghi","sequence":"first","affiliation":[{"name":"Geriatric Mental Health Research Center, Department of Psychiatry, School of Medicine Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirreza","family":"Esmaeili","sequence":"additional","affiliation":[{"name":"Department of Clinical Health Psychology, School of Behavioral Science and Mental Health Iran University of Medical Science  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Pourshams","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences  Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vahid","family":"Saeedi","sequence":"additional","affiliation":[{"name":"Pediatric Growth and Development Research Center, School of Medicine Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Kazem","family":"Malakouti","sequence":"additional","affiliation":[{"name":"Geriatric Mental Health Research Center, Department of Psychiatry, School of Medicine Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2444-7195","authenticated-orcid":false,"given":"Leila","family":"Kamalzadeh","sequence":"additional","affiliation":[{"name":"Geriatric Mental Health Research Center, Department of Psychiatry, School of Medicine Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610214002932"},{"key":"e_1_2_12_3_1","volume-title":"Dementia Statistics","author":"Alzheimer's Disease International (ADI)","year":"2024"},{"issue":"9","key":"e_1_2_12_4_1","first-page":"1184","article-title":"Adaptation and Validation into Portuguese Language of the Six\u2010Item Cognitive Impairment Test (6CIT)","volume":"22","author":"Ap\u00f3stolo J. L. A.","year":"2018","journal-title":"Aging & Mental Health"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1207\/s15324826an1302_4"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13113974"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022\u20103956(75)90026\u20106"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.20098"},{"key":"e_1_2_12_9_1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/978-3-319-44775-9_11","volume-title":"Cognitive Screening Instruments: A Practical Approach","author":"Gale T. 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